Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Distinguishing paracetamol formulations : Comparison of potentiometric “Electronic Tongue” with established analytical techniques. / Belugina, Regina B.; Monakhova, Yulia B.; Rubtsova, Ekaterina; Becht, Alexander; Schollmayer, Curd; Holzgrabe, Ulrike; Legin, Andrey V.; Kirsanov, Dmitry O.
в: Journal of Pharmaceutical and Biomedical Analysis, Том 188, 113457, 05.09.2020.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Distinguishing paracetamol formulations
T2 - Comparison of potentiometric “Electronic Tongue” with established analytical techniques
AU - Belugina, Regina B.
AU - Monakhova, Yulia B.
AU - Rubtsova, Ekaterina
AU - Becht, Alexander
AU - Schollmayer, Curd
AU - Holzgrabe, Ulrike
AU - Legin, Andrey V.
AU - Kirsanov, Dmitry O.
N1 - Funding Information: R.B., A.L. and D.K. acknowledge financial support from Government of Russian Federation Grant 08-08 . Publisher Copyright: © 2020 Elsevier B.V. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/9/5
Y1 - 2020/9/5
N2 - Fast and inexpensive analytical tools for identification of the origin of pharmaceutical formulations are important to ensure consumers safety. This study explores the potential of potentiometric multisensor systems (“electronic tongues”) in this type of application. 72 paracetamol samples purchased in different countries and produced by various companies were studied via infrared spectroscopy (IR), near infrared spectroscopy (NIR), nuclear magnetic resonance spectroscopy (NMR) and multisensor system (ET). A variety of chemometric tools was applied to explore and compare the information yielded by these methods. It was found that ET is capable of distinguishing paracetamol formulations from different producers. The chemical information derived from potentiometric sensor responses has something in common with that derived from NIR and IR; however, it is orthogonal to that from NMR. ET can be a valuable tool in express quality assessment of drugs.
AB - Fast and inexpensive analytical tools for identification of the origin of pharmaceutical formulations are important to ensure consumers safety. This study explores the potential of potentiometric multisensor systems (“electronic tongues”) in this type of application. 72 paracetamol samples purchased in different countries and produced by various companies were studied via infrared spectroscopy (IR), near infrared spectroscopy (NIR), nuclear magnetic resonance spectroscopy (NMR) and multisensor system (ET). A variety of chemometric tools was applied to explore and compare the information yielded by these methods. It was found that ET is capable of distinguishing paracetamol formulations from different producers. The chemical information derived from potentiometric sensor responses has something in common with that derived from NIR and IR; however, it is orthogonal to that from NMR. ET can be a valuable tool in express quality assessment of drugs.
KW - Chemometrics
KW - Multisensor system
KW - Paracetamol
KW - “Electronic tongue”
KW - COUNTERFEIT
KW - "Electronic tongue"
KW - DESIGN
KW - PERFORMANCE
KW - TASTE
KW - LIQUID-CHROMATOGRAPHY
KW - SPECTROSCOPY
KW - DISSOLUTION
KW - PRODUCTS
KW - DRUGS
UR - http://www.scopus.com/inward/record.url?scp=85087766707&partnerID=8YFLogxK
U2 - 10.1016/j.jpba.2020.113457
DO - 10.1016/j.jpba.2020.113457
M3 - Article
C2 - 32663766
AN - SCOPUS:85087766707
VL - 188
JO - Journal of Pharmaceutical and Biomedical Analysis
JF - Journal of Pharmaceutical and Biomedical Analysis
SN - 0731-7085
M1 - 113457
ER -
ID: 70787360