Standard

Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H-2 Antioxidant Species Inside Mitochondria. / Pshenichnyuk, Stanislav A.; Komolov, Alexei S.

в: Journal of Physical Chemistry Letters, Том 6, № 7, 2015, стр. 1104-1110.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Pshenichnyuk, SA & Komolov, AS 2015, 'Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H-2 Antioxidant Species Inside Mitochondria', Journal of Physical Chemistry Letters, Том. 6, № 7, стр. 1104-1110. https://doi.org/10.1021/acs.jpclett.5b00368

APA

Pshenichnyuk, S. A., & Komolov, A. S. (2015). Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H-2 Antioxidant Species Inside Mitochondria. Journal of Physical Chemistry Letters, 6(7), 1104-1110. https://doi.org/10.1021/acs.jpclett.5b00368

Vancouver

Pshenichnyuk SA, Komolov AS. Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H-2 Antioxidant Species Inside Mitochondria. Journal of Physical Chemistry Letters. 2015;6(7):1104-1110. https://doi.org/10.1021/acs.jpclett.5b00368

Author

Pshenichnyuk, Stanislav A. ; Komolov, Alexei S. / Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H-2 Antioxidant Species Inside Mitochondria. в: Journal of Physical Chemistry Letters. 2015 ; Том 6, № 7. стр. 1104-1110.

BibTeX

@article{da19654004e84dd08c2f71e4a8d756ed,
title = "Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H-2 Antioxidant Species Inside Mitochondria",
abstract = "The electron-attaching properties of polyphenolic compound resveratrol were studied in vacuo by means of dissociative electron attachment (DEA) spectroscopy and in silico using density functional theory calculations. The most intense fragments generated by DEA to isolated resveratrol at thermal electron energy are semiquinone anions and neutral hydrogen molecules. On the basis of the present experimental and theoretical data, a new molecular mechanism for the antioxidant activity of resveratrol is presented. It is suggested that the activity of resveratrol in living cells is driven by dissociative attachment of electrons {"}leaked{"} from the respiratory chain to this polyphenolic molecule, followed by the formation of the H-2 antioxidant species inside mitochondria and participation in rnitochondrial energy biogenesis.",
author = "Pshenichnyuk, {Stanislav A.} and Komolov, {Alexei S.}",
year = "2015",
doi = "10.1021/acs.jpclett.5b00368",
language = "English",
volume = "6",
pages = "1104--1110",
journal = "Journal of Physical Chemistry Letters",
issn = "1948-7185",
publisher = "American Chemical Society",
number = "7",

}

RIS

TY - JOUR

T1 - Dissociative Electron Attachment to Resveratrol as a Likely Pathway for Generation of the H-2 Antioxidant Species Inside Mitochondria

AU - Pshenichnyuk, Stanislav A.

AU - Komolov, Alexei S.

PY - 2015

Y1 - 2015

N2 - The electron-attaching properties of polyphenolic compound resveratrol were studied in vacuo by means of dissociative electron attachment (DEA) spectroscopy and in silico using density functional theory calculations. The most intense fragments generated by DEA to isolated resveratrol at thermal electron energy are semiquinone anions and neutral hydrogen molecules. On the basis of the present experimental and theoretical data, a new molecular mechanism for the antioxidant activity of resveratrol is presented. It is suggested that the activity of resveratrol in living cells is driven by dissociative attachment of electrons "leaked" from the respiratory chain to this polyphenolic molecule, followed by the formation of the H-2 antioxidant species inside mitochondria and participation in rnitochondrial energy biogenesis.

AB - The electron-attaching properties of polyphenolic compound resveratrol were studied in vacuo by means of dissociative electron attachment (DEA) spectroscopy and in silico using density functional theory calculations. The most intense fragments generated by DEA to isolated resveratrol at thermal electron energy are semiquinone anions and neutral hydrogen molecules. On the basis of the present experimental and theoretical data, a new molecular mechanism for the antioxidant activity of resveratrol is presented. It is suggested that the activity of resveratrol in living cells is driven by dissociative attachment of electrons "leaked" from the respiratory chain to this polyphenolic molecule, followed by the formation of the H-2 antioxidant species inside mitochondria and participation in rnitochondrial energy biogenesis.

U2 - 10.1021/acs.jpclett.5b00368

DO - 10.1021/acs.jpclett.5b00368

M3 - Article

VL - 6

SP - 1104

EP - 1110

JO - Journal of Physical Chemistry Letters

JF - Journal of Physical Chemistry Letters

SN - 1948-7185

IS - 7

ER -

ID: 3969175