TY - JOUR

T1 - Direct Mechanochemical Oxidation: Sustainable Access to Azine N-Oxides

AU - Байкова, Светлана Олеговна

AU - Солодянкина, Ольга Владимировна

AU - Васильева, Марина Сергеевна

AU - Байков, Сергей Валентинович

AU - Боярский, Вадим Павлович

PY - 2026/5/31

Y1 - 2026/5/31

N2 - A rapid, eco‐friendly mechanochemical protocol for direct oxidation of azines to N ‐oxides was developed. Using m CPBA—the common commercial oxidant—in a ball mill under solvent‐free conditions, the reaction completes in 1 h with yields up to 99%, much faster than traditional solution processes (typically 16–24 h). The protocol exhibits a broad substrate scope, accommodating a wide range of functionalized pyridines, quinolines, isoquinolines, and benzoquinolines bearing diverse substituents (e.g., ethers, halogens, carbonyls, and ureas). The corresponding N ‐oxides are generally obtained in good‐to‐excellent yields without the need for chromatographic purification. Thus, this mechanochemical approach opens a new sustainable avenue in the chemistry of heterocyclic compounds and heteroatom–oxygen bond formation, a field of great importance for medicinal chemistry and materials science.

AB - A rapid, eco‐friendly mechanochemical protocol for direct oxidation of azines to N ‐oxides was developed. Using m CPBA—the common commercial oxidant—in a ball mill under solvent‐free conditions, the reaction completes in 1 h with yields up to 99%, much faster than traditional solution processes (typically 16–24 h). The protocol exhibits a broad substrate scope, accommodating a wide range of functionalized pyridines, quinolines, isoquinolines, and benzoquinolines bearing diverse substituents (e.g., ethers, halogens, carbonyls, and ureas). The corresponding N ‐oxides are generally obtained in good‐to‐excellent yields without the need for chromatographic purification. Thus, this mechanochemical approach opens a new sustainable avenue in the chemistry of heterocyclic compounds and heteroatom–oxygen bond formation, a field of great importance for medicinal chemistry and materials science.

UR - https://aces.onlinelibrary.wiley.com/doi/10.1002/ajoc.70456

UR - https://www.mendeley.com/catalogue/fd330937-43a4-3a73-9810-76fa4ccc495d/

U2 - 10.1002/ajoc.70456

DO - 10.1002/ajoc.70456

M3 - Article

VL - 15

JO - Asian Journal of Organic Chemistry

JF - Asian Journal of Organic Chemistry

SN - 2193-5807

IS - 6

M1 - e70456

ER -