DOI

While the number of sequenced diploid genomes have been steadily increasing in the last few years, assembly of highly polymorphic (HP) diploid genomes remains challenging. As a result, there is a shortage of tools for assembling HP genomes from the next generation sequencing (NGS) data. The initial approaches to assembling HP genomes were proposed in the pre-NGS era and are not well suited for NGS projects. To address this limitation, we developed the first de Bruijn graph assembler, dipSPAdes, for HP genomes that significantly improves on the state-of-the-art assemblers for HP diploid genomes.

Язык оригиналаанглийский
Страницы (с-по)528-545
Число страниц18
ЖурналJournal of Computational Biology
Том22
Номер выпуска6
DOI
СостояниеОпубликовано - 1 июн 2015
Опубликовано для внешнего пользованияДа

    Предметные области Scopus

  • Моделирование и симуляция
  • Молекулярная биология
  • Генетика
  • Вычислительная математика
  • Математика и теория расчета

ID: 28583338