Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Dinamika nadkhodzhennia gamk ta ǐǐ spoluki z pantoatom viddili golovnogo mozku mishei. / Rozanov, V. A.; Kopelevich, V. M.; Savits'kiǐ, I. V.; Rozanov, A. I.
в: Ukrains"kyi biokhimichnyi zhurnal, Том 49, № 6, 01.11.1977, стр. 34-38.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Dinamika nadkhodzhennia gamk ta ǐǐ spoluki z pantoatom viddili golovnogo mozku mishei.
AU - Rozanov, V. A.
AU - Kopelevich, V. M.
AU - Savits'kiǐ, I. V.
AU - Rozanov, A. I.
PY - 1977/11/1
Y1 - 1977/11/1
N2 - After subcutaneous administration in equimolar, close to therapeutic, doses accumulation of 1-14C-PANTOGAB exceeds accumulation of 1-14C-GABA in the brain areas only at early stages of observations: 7.5 and 15 min. In blood at all the time except for 4 h, the amount of 1-14C-PANTOGAB exceeds essentially the content of 1-14C-GABA. Maximum of 14C-PANTOGAB accumulation in the brain is observed 30 min later and that of 14C-GABA by 60 min. Difference in distribution of both preparations between the brain areas are inconsiderable. In the period of maximum accumulation there is a tendency to a more intensive 1-14C-PANTOGAB incorporation into the cerebellum, and 1-14C-GABA into truncus cerebri. The dynamics of accumulation in the brain and removing of the studied compounds from blood evidences for better absorption from the place of administration and for a weaker biotransformation of PANTOGAB as compared to GABA.
AB - After subcutaneous administration in equimolar, close to therapeutic, doses accumulation of 1-14C-PANTOGAB exceeds accumulation of 1-14C-GABA in the brain areas only at early stages of observations: 7.5 and 15 min. In blood at all the time except for 4 h, the amount of 1-14C-PANTOGAB exceeds essentially the content of 1-14C-GABA. Maximum of 14C-PANTOGAB accumulation in the brain is observed 30 min later and that of 14C-GABA by 60 min. Difference in distribution of both preparations between the brain areas are inconsiderable. In the period of maximum accumulation there is a tendency to a more intensive 1-14C-PANTOGAB incorporation into the cerebellum, and 1-14C-GABA into truncus cerebri. The dynamics of accumulation in the brain and removing of the studied compounds from blood evidences for better absorption from the place of administration and for a weaker biotransformation of PANTOGAB as compared to GABA.
UR - http://www.scopus.com/inward/record.url?scp=0017552672&partnerID=8YFLogxK
M3 - статья
C2 - 929708
AN - SCOPUS:0017552672
VL - 49
SP - 34
EP - 38
JO - Ukrainian biochemical journal
JF - Ukrainian biochemical journal
SN - 2409-4943
IS - 6
ER -
ID: 42772519