Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The effects of an imidazoline compound (BL11282) on protein expression in rat pancreatic islets were investigated with a proteomic approach. The compound increases insulin release selectively at high glucose concentrations and is therefore of interest in type 2 diabetes. Whole cell extracts from isolated drug-treated and native pancreatic rat islets were compared after separation by 2-D gel electrophoresis. Differentially expressed proteins were identified by mass spectrometry; 15 proteins were selectively up-regulated and 7 selectively down-regulated in drug-treated islets. Of special interest among the differentially expressed proteins are those involved in protein folding (Hsp60, protein disulfide isomerase, calreticulin), Ca2+ binding (calgizzarin, calcyclin and annexin I) and metabolism or signalling (pyruvate kinase, alpha enolase and protein kinase C inhibitor 1).
Язык оригинала | английский |
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Страницы (с-по) | 1310-1316 |
Число страниц | 7 |
Журнал | Cellular and Molecular Life Sciences |
Том | 64 |
Номер выпуска | 10 |
DOI | |
Состояние | Опубликовано - мая 2007 |
ID: 5533079