Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Dicationic protic ionic liquids based on N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine. / Kondratenko, Yulia A.; Makovskaya, Olga N.; Antuganov, Dmitrii O.; Zolotarev, Andrey A.; Ugolkov, Valery L.; Nadporojskii, Michail A.; Kochina, Tatyana A.
в: Journal of Molecular Liquids, Том 363, 119891, 01.10.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Dicationic protic ionic liquids based on N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine
AU - Kondratenko, Yulia A.
AU - Makovskaya, Olga N.
AU - Antuganov, Dmitrii O.
AU - Zolotarev, Andrey A.
AU - Ugolkov, Valery L.
AU - Nadporojskii, Michail A.
AU - Kochina, Tatyana A.
N1 - Publisher Copyright: © 2022 Elsevier B.V.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - The interaction of N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine with carboxylic acids resulted in a new series of dicationic protic alkanolammonium ionic liquids (PAAILs). New PAAILs were characterized by NMR, FTIR spectroscopy, and thermal analysis. The conformation of N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediammonium cations and intermolecular interactions in salts of 1-hydroxy-2-naphthoic and oxalic acids were studied using X-ray diffraction supplemented by Hirshfeld surfaces analysis. Some pharmacokinetic parameters of the synthesized dicationic PAAILs have been predicted to evaluate their potential biomedical applications. In comparison with monocationic PAAILs, their antimicrobial and buffering activity in 68Ga-radiolabeling reactions of chelating agents and clinically relevant peptides were studied.
AB - The interaction of N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine with carboxylic acids resulted in a new series of dicationic protic alkanolammonium ionic liquids (PAAILs). New PAAILs were characterized by NMR, FTIR spectroscopy, and thermal analysis. The conformation of N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediammonium cations and intermolecular interactions in salts of 1-hydroxy-2-naphthoic and oxalic acids were studied using X-ray diffraction supplemented by Hirshfeld surfaces analysis. Some pharmacokinetic parameters of the synthesized dicationic PAAILs have been predicted to evaluate their potential biomedical applications. In comparison with monocationic PAAILs, their antimicrobial and buffering activity in 68Ga-radiolabeling reactions of chelating agents and clinically relevant peptides were studied.
KW - Antimicrobial activity
KW - Buffers for Ga-radiolabeling reactions
KW - Dicationic protic ionic liquids
KW - Hirshfeld surface analysis
KW - Lipinski's rule
KW - N,N,N',N'-tetrakis(2-hydroxyethyl)ethylenediamine
UR - http://www.scopus.com/inward/record.url?scp=85134883623&partnerID=8YFLogxK
U2 - 10.1016/j.molliq.2022.119891
DO - 10.1016/j.molliq.2022.119891
M3 - Article
AN - SCOPUS:85134883623
VL - 363
JO - Journal of Molecular Liquids
JF - Journal of Molecular Liquids
SN - 0167-7322
M1 - 119891
ER -
ID: 99016565