TY - JOUR

T1 - Dialysis start timing

T2 - Development and validation of start scoring scale

AU - Zemchenkov, A. Yu

AU - Gerasimchuk, R. P.

AU - Sabodash, A. B.

AU - Vishnevskii, K. A.

AU - Zemchenkov, G. A.

AU - Omelchenko, A. M.

AU - Kulaeva, N. N.

AU - Konakova, I. N.

AU - Yakovenko, A. A.

AU - Rumyantsev, A. Sh

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Aim. The optimal time for initiating of chronic dialysis remains unknown. The scale for mortality risk assessment could help in decision-making concerning dialysis start timing. Methods. We randomly divided 1856 patients started dialysis in 2009–2016 into developmental and validation group (1:1) to create and validate scoring system «START» predicting mortality risk at dialysis initiation in order to find unmodifiable and modifiable factors which could help in the decision-making of dialysis start. In the series of univariate regression models in the developmental set, we evaluated the mortality risk linked with available parameters: age, eGFR, serum phosphate, total calcium, hemoglobin, Charlson comorbidity index, diabetes status, urgency of start (turned to be significant) and gender, serum sodium, potassium, blood pressure (without impact on survival). Similar hazard ratios were converted to score points. Results. The START score was highly predictive of death: C-statistic was 0.82 (95% CI 0.79–0.85) for the developmental dataset and 0.79 (95% CI 0.74–0.84) for validation dataset (both p < 0.001). On applying the cutoff between 7–8 points in the developmental dataset, the risk score was highly sensitive 81.1% and specific 67.9%; for validation dataset, the sensitivity was 78.9%, specificity 67.9%. We confirmed the similarity in survival prediction in the validation set to developmental set in low, medium and high START score groups. The difference in survival between three levels of START-score in validation set remained similar to that of developmental set: Wilcoxon = 8.78 (p = 0.02) vs 15.31 (p < 0.001) comparing low–medium levels and 25.18 (p < 0.001) vs 39.21 (p < 0.001) comparing medium–high levels. Conclusion. Developed START score system including modifiable factors showed good mortality prediction and could be used in dialysis start decision-making.

AB - Aim. The optimal time for initiating of chronic dialysis remains unknown. The scale for mortality risk assessment could help in decision-making concerning dialysis start timing. Methods. We randomly divided 1856 patients started dialysis in 2009–2016 into developmental and validation group (1:1) to create and validate scoring system «START» predicting mortality risk at dialysis initiation in order to find unmodifiable and modifiable factors which could help in the decision-making of dialysis start. In the series of univariate regression models in the developmental set, we evaluated the mortality risk linked with available parameters: age, eGFR, serum phosphate, total calcium, hemoglobin, Charlson comorbidity index, diabetes status, urgency of start (turned to be significant) and gender, serum sodium, potassium, blood pressure (without impact on survival). Similar hazard ratios were converted to score points. Results. The START score was highly predictive of death: C-statistic was 0.82 (95% CI 0.79–0.85) for the developmental dataset and 0.79 (95% CI 0.74–0.84) for validation dataset (both p < 0.001). On applying the cutoff between 7–8 points in the developmental dataset, the risk score was highly sensitive 81.1% and specific 67.9%; for validation dataset, the sensitivity was 78.9%, specificity 67.9%. We confirmed the similarity in survival prediction in the validation set to developmental set in low, medium and high START score groups. The difference in survival between three levels of START-score in validation set remained similar to that of developmental set: Wilcoxon = 8.78 (p = 0.02) vs 15.31 (p < 0.001) comparing low–medium levels and 25.18 (p < 0.001) vs 39.21 (p < 0.001) comparing medium–high levels. Conclusion. Developed START score system including modifiable factors showed good mortality prediction and could be used in dialysis start decision-making.

KW - Dialysis start

KW - Estimated glomerular filtration rate

KW - Mortality prediction

KW - Risk assessment

UR - http://www.scopus.com/inward/record.url?scp=85050073372&partnerID=8YFLogxK

U2 - 10.15825/1995-1191-2018-2-47-60

DO - 10.15825/1995-1191-2018-2-47-60

M3 - Article

AN - SCOPUS:85050073372

VL - 20

SP - 47

EP - 60

JO - ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ

JF - ВЕСТНИК ТРАНСПЛАНТОЛОГИИ И ИСКУССТВЕННЫХ ОРГАНОВ

SN - 1995-1191

IS - 2

ER -