Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Dextran hydrofobically modified by sterically hindered phenols. / Filippov, S.K.; Porsch, B.; Sergeeva, O.Yu.; Olifirenko, A.S.; Lesnichin, S.B.; Domnina, N.S.; Komarova, E.A.; Lezov, A.V.; Garamus, V.M.; Walterova, Z.; Stepanek, P.
в: European Physical Journal E, Том 34, № 11, 2011, стр. 123-132.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Dextran hydrofobically modified by sterically hindered phenols
AU - Filippov, S.K.
AU - Porsch, B.
AU - Sergeeva, O.Yu.
AU - Olifirenko, A.S.
AU - Lesnichin, S.B.
AU - Domnina, N.S.
AU - Komarova, E.A.
AU - Lezov, A.V.
AU - Garamus, V.M.
AU - Walterova, Z.
AU - Stepanek, P.
PY - 2011
Y1 - 2011
N2 - The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity —polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure.
AB - The conformation properties of clinically relevant hybrid macromolecular antioxidants (dextran hydrophobically modified by sterically hindered phenols) in aqueous solution were characterized by a combination of dynamic light scattering (DLS), size exclusion chromatography (SEC), and small-angle neutron scattering (SANS). We were able to split and analyze separately two different types of polydispersity —polydispersity over molecular weights and the one over substitution degree. The properties of the hybrid macromolecules are determined by the number of hydrophobic antioxidants in a single molecule. An insertion of hydrophobic groups into a hydrophilic chain changes the conformation of a single conjugate macromolecule. We have established that with the increasing of a number of hydrophobic antioxidant groups, a conformational transition occurs where a single conjugate undergoes a transition from a Gaussian coil conformation to a more compact structure.
U2 - 10.1140/epje/i2011-11123-7
DO - 10.1140/epje/i2011-11123-7
M3 - Article
VL - 34
SP - 123
EP - 132
JO - European Physical Journal E
JF - European Physical Journal E
SN - 1292-8941
IS - 11
ER -
ID: 5358983