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Dexamethasone conjugates : Synthetic approaches and medical prospects. / Dubashynskaya, Natallia V.; Bokatyi, Anton N.; Skorik, Yury A.

в: Biomedicines, Том 9, № 4, 341, 27.03.2021.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

Harvard

Dubashynskaya, NV, Bokatyi, AN & Skorik, YA 2021, 'Dexamethasone conjugates: Synthetic approaches and medical prospects', Biomedicines, Том. 9, № 4, 341. https://doi.org/10.3390/biomedicines9040341

APA

Dubashynskaya, N. V., Bokatyi, A. N., & Skorik, Y. A. (2021). Dexamethasone conjugates: Synthetic approaches and medical prospects. Biomedicines, 9(4), [341]. https://doi.org/10.3390/biomedicines9040341

Vancouver

Dubashynskaya NV, Bokatyi AN, Skorik YA. Dexamethasone conjugates: Synthetic approaches and medical prospects. Biomedicines. 2021 Март 27;9(4). 341. https://doi.org/10.3390/biomedicines9040341

Author

Dubashynskaya, Natallia V. ; Bokatyi, Anton N. ; Skorik, Yury A. / Dexamethasone conjugates : Synthetic approaches and medical prospects. в: Biomedicines. 2021 ; Том 9, № 4.

BibTeX

@article{135cac73804c42d78eb90ce3ee1f5112,
title = "Dexamethasone conjugates: Synthetic approaches and medical prospects",
abstract = "Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side effects on non-target organs. One strategy to reduce these side effects is to develop targeted systems with the controlled release by conjugation to polymeric carriers. This review describes the methods available for the synthesis of DEX conjugates (carbodiimide chemistry, solid-phase synthesis, reversible addition fragmentation-chain transfer [RAFT] polymerization, click reactions, and 2-iminothiolane chemistry) and perspectives for their medical application as GC drug or gene delivery systems for anti-tumor therapy. Additionally, the review focuses on the development of DEX conjugates with different physical-chemical properties as successful delivery systems in the target organs such as eye, joint, kidney, and others. Finally, polymer conjugates with improved transfection activity in which DEX is used as a vector for gene delivery in the cell nucleus have been described.",
keywords = "Biopoly-mers, Dexamethasone, Drug conjugate, Drug delivery system, Gene delivery system",
author = "Dubashynskaya, {Natallia V.} and Bokatyi, {Anton N.} and Skorik, {Yury A.}",
note = "Publisher Copyright: {\textcopyright} 2021 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2021",
month = mar,
day = "27",
doi = "10.3390/biomedicines9040341",
language = "English",
volume = "9",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI AG",
number = "4",

}

RIS

TY - JOUR

T1 - Dexamethasone conjugates

T2 - Synthetic approaches and medical prospects

AU - Dubashynskaya, Natallia V.

AU - Bokatyi, Anton N.

AU - Skorik, Yury A.

N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2021/3/27

Y1 - 2021/3/27

N2 - Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side effects on non-target organs. One strategy to reduce these side effects is to develop targeted systems with the controlled release by conjugation to polymeric carriers. This review describes the methods available for the synthesis of DEX conjugates (carbodiimide chemistry, solid-phase synthesis, reversible addition fragmentation-chain transfer [RAFT] polymerization, click reactions, and 2-iminothiolane chemistry) and perspectives for their medical application as GC drug or gene delivery systems for anti-tumor therapy. Additionally, the review focuses on the development of DEX conjugates with different physical-chemical properties as successful delivery systems in the target organs such as eye, joint, kidney, and others. Finally, polymer conjugates with improved transfection activity in which DEX is used as a vector for gene delivery in the cell nucleus have been described.

AB - Dexamethasone (DEX) is the most commonly prescribed glucocorticoid (GC) and has a wide spectrum of pharmacological activity. However, steroid drugs like DEX can have severe side effects on non-target organs. One strategy to reduce these side effects is to develop targeted systems with the controlled release by conjugation to polymeric carriers. This review describes the methods available for the synthesis of DEX conjugates (carbodiimide chemistry, solid-phase synthesis, reversible addition fragmentation-chain transfer [RAFT] polymerization, click reactions, and 2-iminothiolane chemistry) and perspectives for their medical application as GC drug or gene delivery systems for anti-tumor therapy. Additionally, the review focuses on the development of DEX conjugates with different physical-chemical properties as successful delivery systems in the target organs such as eye, joint, kidney, and others. Finally, polymer conjugates with improved transfection activity in which DEX is used as a vector for gene delivery in the cell nucleus have been described.

KW - Biopoly-mers

KW - Dexamethasone

KW - Drug conjugate

KW - Drug delivery system

KW - Gene delivery system

UR - http://www.scopus.com/inward/record.url?scp=85104008378&partnerID=8YFLogxK

U2 - 10.3390/biomedicines9040341

DO - 10.3390/biomedicines9040341

M3 - Review article

AN - SCOPUS:85104008378

VL - 9

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 4

M1 - 341

ER -

ID: 91957948