Результаты исследований: Научные публикации в периодических изданиях › статья
Development of MHC-linked microsatellite markers in the domestic cat and their use to evaluate MHC diversity in domestic cats, cheetahs, and gir lions. / Morris, K.M.; Kirby, K.; Beatty, J.A.; Barrs, V.R.; Cattley, S.; David, V.; O'Brien, S.J.; Menotti-Raymond, M.; Belov, K.
в: Journal of Heredity, № 4, 2014, стр. 493-505.Результаты исследований: Научные публикации в периодических изданиях › статья
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TY - JOUR
T1 - Development of MHC-linked microsatellite markers in the domestic cat and their use to evaluate MHC diversity in domestic cats, cheetahs, and gir lions
AU - Morris, K.M.
AU - Kirby, K.
AU - Beatty, J.A.
AU - Barrs, V.R.
AU - Cattley, S.
AU - David, V.
AU - O'Brien, S.J.
AU - Menotti-Raymond, M.
AU - Belov, K.
PY - 2014
Y1 - 2014
N2 - Diversity within the major histocompatibility complex (MHC) reflects the immunological fitness of a population. MHC-linked microsatellite markers provide a simple and an inexpensive method for studying MHC diversity in large-scale studies. We have developed 6 MHC-linked microsatellite markers in the domestic cat and used these, in conjunction with 5 neutral microsatellites, to assess MHC diversity in domestic mixed breed (n = 129) and purebred Burmese (n = 61) cat populations in Australia. The MHC of outbred Australian cats is polymorphic (average allelic richness = 8.52), whereas the Burmese population has significantly lower MHC diversity (average allelic richness = 6.81; P <0.01). The MHC-linked microsatellites along with MHC cloning and sequencing demonstrated moderate MHC diversity in cheetahs (n = 13) and extremely low diversity in Gir lions (n = 13). Our MHC-linked microsatellite markers have potential future use in diversity and disease studies in other populations and breeds of cats as well as in wi
AB - Diversity within the major histocompatibility complex (MHC) reflects the immunological fitness of a population. MHC-linked microsatellite markers provide a simple and an inexpensive method for studying MHC diversity in large-scale studies. We have developed 6 MHC-linked microsatellite markers in the domestic cat and used these, in conjunction with 5 neutral microsatellites, to assess MHC diversity in domestic mixed breed (n = 129) and purebred Burmese (n = 61) cat populations in Australia. The MHC of outbred Australian cats is polymorphic (average allelic richness = 8.52), whereas the Burmese population has significantly lower MHC diversity (average allelic richness = 6.81; P <0.01). The MHC-linked microsatellites along with MHC cloning and sequencing demonstrated moderate MHC diversity in cheetahs (n = 13) and extremely low diversity in Gir lions (n = 13). Our MHC-linked microsatellite markers have potential future use in diversity and disease studies in other populations and breeds of cats as well as in wi
U2 - 10.1093/jhered/esu017
DO - 10.1093/jhered/esu017
M3 - Article
SP - 493
EP - 505
JO - Journal of Heredity
JF - Journal of Heredity
SN - 0022-1503
IS - 4
ER -
ID: 7066134