Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Developing zebrafish experimental animal models relevant to schizophrenia. / Demin, Konstantin A.; Meshalkina, Darya A.; Volgin, Andrey D.; Yakovlev, Oleg V.; de Abreu, Murilo S.; Alekseeva, Polina A.; Friend, Ashton J.; Lakstygal, Anton M.; Zabegalov, Konstantin; Amstislavskaya, Tamara G.; Strekalova, Tatyana; Bao, Wandong; Kalueff, Allan V.
в: Neuroscience and Biobehavioral Reviews, Том 105, 10.2019, стр. 126-133.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
}
TY - JOUR
T1 - Developing zebrafish experimental animal models relevant to schizophrenia
AU - Demin, Konstantin A.
AU - Meshalkina, Darya A.
AU - Volgin, Andrey D.
AU - Yakovlev, Oleg V.
AU - de Abreu, Murilo S.
AU - Alekseeva, Polina A.
AU - Friend, Ashton J.
AU - Lakstygal, Anton M.
AU - Zabegalov, Konstantin
AU - Amstislavskaya, Tamara G.
AU - Strekalova, Tatyana
AU - Bao, Wandong
AU - Kalueff, Allan V.
PY - 2019/10
Y1 - 2019/10
N2 - Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.
AB - Schizophrenia is a severely debilitating, lifelong psychiatric disorder affecting approximately 1% of global population. The pathobiology of schizophrenia remains poorly understood, necessitating further translational research in this field. Experimental (animal) models are becoming indispensable for studying schizophrenia-related phenotypes and pro/antipsychotic drugs. Mounting evidence suggests the zebrafish (Danio rerio) as a useful tool to model various phenotypes relevant to schizophrenia. In addition to their complex robust behaviors, zebrafish possess high genetic and physiological homology to humans, and are also sensitive to drugs known to reduce or promote schizophrenia clinically. Here, we summarize findings on zebrafish application to modeling schizophrenia, as well as discuss recent progress and remaining challenges in this field. We also emphasize the need in further development and wider use of zebrafish models for schizophrenia to better understand its pathogenesis and enhance the search for new effective antipsychotics.
KW - Negative symptoms
KW - Positive symptoms
KW - Rodent models
KW - Schizophrenia
KW - Translational research
KW - Zebrafish
UR - http://www.scopus.com/inward/record.url?scp=85070349656&partnerID=8YFLogxK
UR - http://www.mendeley.com/research/developing-zebrafish-experimental-animal-models-relevant-schizophrenia
U2 - 10.1016/j.neubiorev.2019.07.017
DO - 10.1016/j.neubiorev.2019.07.017
M3 - Review article
C2 - 31369798
AN - SCOPUS:85070349656
VL - 105
SP - 126
EP - 133
JO - Neuroscience and Biobehavioral Reviews
JF - Neuroscience and Biobehavioral Reviews
SN - 0149-7634
ER -
ID: 46340233