TY - JOUR

T1 - Developing translational biological psychiatry: learning from history to build the future

AU - Demin, Konstantin

AU - Meshalkina, Darya

AU - Lakstygal, Anton

AU - Kalueff, Allan

PY - 2018/5/4

Y1 - 2018/5/4

N2 - Psychiatric disorders are among the most complex human disorders that, albeitoften difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous systemas mental disorders develop. Today’s biological psychiatry is facing multipleconceptual problems that prevent our deeper understanding of disease pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.

AB - Psychiatric disorders are among the most complex human disorders that, albeitoften difficult to diagnose and treat, are widespread in modern society. Biological psychiatry studies biological functions of the central nervous systemas mental disorders develop. Today’s biological psychiatry is facing multipleconceptual problems that prevent our deeper understanding of disease pathogenesis and delay the invention of new treatments. Thus, providing a historical context to this rapidly developing field may help scientists better understand the existing challenges and their potential solutions. Here, we discuss the main conceptual problems and paradigms of biological psychiatry, including the lack of reproducibility and/or valid theories, through an historical overview of its role in addressing theoretical and clinical questions. We propose a wider use of the translational approach in psychiatry to expand our analyses of psychiatric disorders to other species, and as a tool to create and further develop theories and concepts in this field.

KW - Biological psychiatry

KW - translational medicine

KW - history of psychiatry

KW - modern psychiatry

KW - conceptual issues in psychiatry

UR - https://elibrary.ru/item.asp?id=35183188

M3 - Review article

VL - 62

SP - 278

EP - 292

JO - Biological Communications

JF - Biological Communications

SN - 2542-2154

IS - 4

ER -