Modern analytical chemistry is a highly multidisciplinary research field, and advances within one branch are often adopted by neighbouring research directions. This is especially true in liquid extraction and sensor development fields. The elementary act of binding of a target ion with an organic ligand is of crucial importance in both of these research areas. This chapter reviews how one can use data and substances developed for liquid extraction of various metals to prepare chemical sensors that can be employed in multisensor systems for simultaneous determination of several metals in complex mixtures. Three case studies involving sensor arrays employing various extracting agents of different chemical nature are described.