TY - JOUR

T1 - Determination Of Significant Diagnostic Criteria For The Development Of Primary Open-Angle Glaucoma Based On A Comprehensive Statistical Analysis Of Biomechanical And Hemodynamic Parameters Of The Eye

AU - Iomdina, E. N.

AU - Kornikov, V. V.

AU - Bauer, S. M.

AU - Khoziev, D. D.

AU - Moiseeva, I. N.

AU - Stein, A. A.

AU - Luzhnov, P. V.

N1 - Publisher Copyright: © Iomdina E.N., Kornikov V.V., Bauer S.M., Khoziev D.D., Moiseeva I.N., Stein A.A., Luzhnov P.V., 2021 Elena N. Iomdina, Ph.D., Professor, Principal Researcher of Department of Refractive Pathology, Binocular Vision and Ophthalmoergonomics, Moscow Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - A complex statistical (correlation, discriminant, factorial) analysis of a set of parameters -biomechanical characteristics of the corneoscleral shell of the eye, hemodynamic parameters and perimetric indices, determined during examination of 110 eyes, including 69 eyes with various stages of primary open-angle glaucoma (POAG) and 41 eyes without ophthalmopathology – was carried out. Significantly correlated parameters characteristic of a particular stage of POAG were identified. The set of identified correlations characterizes progressive glaucoma damage as a process associated with a simultaneous change in the biomechanics of the eye shells and the scleral lamina cribrosa, as well as the blood supply to the choroid and retina, which, apparently, underlies the gradual deterioration of its photosensitivity and changes in the visual field. It was found that correlations within groups of patients with various stages of POAG change significantly with the progression of glaucomatous process, and, possibly, reflect the change in the contribution of biomechanical and hemodynamical disorders to the development of glaucomatous lesion at the corresponding stage of its development.

AB - A complex statistical (correlation, discriminant, factorial) analysis of a set of parameters -biomechanical characteristics of the corneoscleral shell of the eye, hemodynamic parameters and perimetric indices, determined during examination of 110 eyes, including 69 eyes with various stages of primary open-angle glaucoma (POAG) and 41 eyes without ophthalmopathology – was carried out. Significantly correlated parameters characteristic of a particular stage of POAG were identified. The set of identified correlations characterizes progressive glaucoma damage as a process associated with a simultaneous change in the biomechanics of the eye shells and the scleral lamina cribrosa, as well as the blood supply to the choroid and retina, which, apparently, underlies the gradual deterioration of its photosensitivity and changes in the visual field. It was found that correlations within groups of patients with various stages of POAG change significantly with the progression of glaucomatous process, and, possibly, reflect the change in the contribution of biomechanical and hemodynamical disorders to the development of glaucomatous lesion at the corresponding stage of its development.

KW - biomechanical properties of corneascleral shell

KW - discriminant analysis

KW - eye hemodynamics

KW - intraocular pressure

KW - Kolmogorov–Smirnov criterion

KW - lamina cribrosa

KW - primary open angle glaucoma

UR - http://www.scopus.com/inward/record.url?scp=85104709157&partnerID=8YFLogxK

U2 - 10.15593/RJBiomech/2021.1.01

DO - 10.15593/RJBiomech/2021.1.01

M3 - Article

AN - SCOPUS:85104709157

VL - 25

SP - 5

EP - 15

JO - РОССИЙСКИЙ ЖУРНАЛ БИОМЕХАНИКИ

JF - РОССИЙСКИЙ ЖУРНАЛ БИОМЕХАНИКИ

SN - 1812-5123

IS - 1

ER -