TY - JOUR

T1 - Detection of tyrosine using metal nanoclusters

AU - Капитонова, Марина Анатольевна

AU - Ревегук, Захар Вячеславович

AU - Сыч, Томаш Сергеевич

AU - Чуйко, Яна Владимировна

AU - Кононов, Алексей Игоревич

AU - Буглак, Андрей Андреевич

N1 - Conference code: 45

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Tyr is involved in the synthesis of neurotransmitters, catecholamines, thyroid hormones, etc. There is a number of pathologies associated with impaired Tyr metabolism: phenylketonuria, hypothyroidism, tyrosinemia, alkaptonuria, and vitiligo. We have shown the possibility of Ag nanocluster (NC) synthesison Tyr. Ag NC can be applied for SERS and fluorescent Tyrdetection. However, prior to development of Tyr biosensor oneshould understand the theoretical basics of interactions betweenTyr and NCs. We calculated the binding energy (Eb) betweenTyr and Agnz (n = 2–8; z = 0–1) NCs using DFT-D3 method.PBE functional with 6-31G(d,p) basis set.

AB - Tyr is involved in the synthesis of neurotransmitters, catecholamines, thyroid hormones, etc. There is a number of pathologies associated with impaired Tyr metabolism: phenylketonuria, hypothyroidism, tyrosinemia, alkaptonuria, and vitiligo. We have shown the possibility of Ag nanocluster (NC) synthesison Tyr. Ag NC can be applied for SERS and fluorescent Tyrdetection. However, prior to development of Tyr biosensor oneshould understand the theoretical basics of interactions betweenTyr and NCs. We calculated the binding energy (Eb) betweenTyr and Agnz (n = 2–8; z = 0–1) NCs using DFT-D3 method.PBE functional with 6-31G(d,p) basis set.

UR - https://www.mendeley.com/catalogue/52ab11ab-36aa-382c-a930-7980f9c02805/

U2 - 10.1002/2211-5463.13205

DO - 10.1002/2211-5463.13205

M3 - Meeting Abstract

VL - 11

SP - 270

EP - 270

JO - FEBS Open Bio

JF - FEBS Open Bio

SN - 2211-5463

IS - S1

T2 - 45th FEBS Congress, Molecules of Life: Towards New Horizons

Y2 - 3 July 2021 through 8 July 2021

ER -