TY - JOUR

T1 - Delete and survive: strategies of programmed genetic material elimination in eukaryotes

AU - Dedukh, Dmitrij

AU - Krasikova, Alla

N1 - Publisher Copyright: © 2021 The Authors. Biological Reviews published by John Wiley & Sons Ltd on behalf of Cambridge Philosophical Society.

PY - 2021/9/20

Y1 - 2021/9/20

N2 - Genome stability is a crucial feature of eukaryotic organisms because its alteration drastically affects the normal development and survival of cells and the organism as a whole. Nevertheless, some organisms can selectively eliminate part of their genomes from certain cell types during specific stages of ontogenesis. This review aims to describe the phenomenon of programmed DNA elimination, which includes chromatin diminution (together with programmed genome rearrangement or DNA rearrangements), B and sex chromosome elimination, paternal genome elimination, parasitically induced genome elimination, and genome elimination in animal and plant hybrids. During programmed DNA elimination, individual chromosomal fragments, whole chromosomes, and even entire parental genomes can be selectively removed. Programmed DNA elimination occurs independently in different organisms, ranging from ciliate protozoa to mammals. Depending on the sequences destined for exclusion, programmed DNA elimination may serve as a radical mechanism of dosage compensation and inactivation of unnecessary or dangerous genetic entities. In hybrids, genome elimination results from competition between parental genomes. Despite the different consequences of DNA elimination, all genetic material destined for elimination must be first recognised, epigenetically marked, separated, and then removed and degraded.

AB - Genome stability is a crucial feature of eukaryotic organisms because its alteration drastically affects the normal development and survival of cells and the organism as a whole. Nevertheless, some organisms can selectively eliminate part of their genomes from certain cell types during specific stages of ontogenesis. This review aims to describe the phenomenon of programmed DNA elimination, which includes chromatin diminution (together with programmed genome rearrangement or DNA rearrangements), B and sex chromosome elimination, paternal genome elimination, parasitically induced genome elimination, and genome elimination in animal and plant hybrids. During programmed DNA elimination, individual chromosomal fragments, whole chromosomes, and even entire parental genomes can be selectively removed. Programmed DNA elimination occurs independently in different organisms, ranging from ciliate protozoa to mammals. Depending on the sequences destined for exclusion, programmed DNA elimination may serve as a radical mechanism of dosage compensation and inactivation of unnecessary or dangerous genetic entities. In hybrids, genome elimination results from competition between parental genomes. Despite the different consequences of DNA elimination, all genetic material destined for elimination must be first recognised, epigenetically marked, separated, and then removed and degraded.

KW - asexual hybrids

KW - B chromosomes

KW - chromatin diminution

KW - chromosomal lagging

KW - micronuclei

KW - programmed DNA elimination

KW - sex chromosomes

KW - SCALE INSECTS COCCOIDEA

KW - X-CHROMOSOME

KW - CHROMATIN DIMINUTION

KW - HISTONE H3 PHOSPHORYLATION

KW - CLAM CORBICULA-LEANA

KW - SELFISH B-CHROMOSOME

KW - DNA ELIMINATION

KW - ACRICOTOPUS-LUCIDUS DIPTERA

KW - SEX-RATIO CHROMOSOME

KW - ALL-FEMALE FISH

UR - http://www.scopus.com/inward/record.url?scp=85115074656&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/3eb04039-78cd-3d5c-b8af-ebe7a5201387/

U2 - 10.1111/brv.12796

DO - 10.1111/brv.12796

M3 - Article

AN - SCOPUS:85115074656

JO - Biological Reviews

JF - Biological Reviews

SN - 1464-7931

ER -