TY - JOUR

T1 - Declínio da memória episódica relacionado à idade e o papel da beta-amiloide

T2 - Uma revisão sistemática

AU - Souto, Jandirlly Julianna

AU - Silva, Gabriella Medeiros

AU - Almeida, Natalia Leandro

AU - Shoshina, Irina Ivanovna

AU - Santos, Natanael Antonio

AU - Fernandes, Thiago Paiva

N1 - Publisher Copyright: © 2021, Associacao Arquivos de Neuro-Psiquiatria. All rights reserved.

PY - 2021/10/12

Y1 - 2021/10/12

N2 - Aging has been associated with the functional decline of episodic memory (EM). Unanswered questions are whether the decline of EM occurs even during healthy aging and whether this decline is related to amyloid-β (Aβ) deposition in the hippocampus. Objective: The main purpose of this study was to investigate data on the relationship between the age-related EM decline and Aβ deposition. Methods: We searched the Cochrane, MEDLINE, Scopus, and Web of Science databases and reference lists of retrieved articles that were published in the past 10 years. The initial literature search identified 517 studies. After screening the title, abstract, key words, and reference lists, 56 studies met the inclusion criteria. Results: The overall results revealed that increases in Aβ are related to lower hippocampal volume and worse performance on EM tests. The results of this systematic review revealed that high levels of Aβ may be related to EM deficits and the progression to Alzheimer’s disease. Conclusions: We discussed the strengths and pitfalls of various tests and techniques used for investigating EM and Aβ deposition, methodological issues, and potential directions for future research.

AB - Aging has been associated with the functional decline of episodic memory (EM). Unanswered questions are whether the decline of EM occurs even during healthy aging and whether this decline is related to amyloid-β (Aβ) deposition in the hippocampus. Objective: The main purpose of this study was to investigate data on the relationship between the age-related EM decline and Aβ deposition. Methods: We searched the Cochrane, MEDLINE, Scopus, and Web of Science databases and reference lists of retrieved articles that were published in the past 10 years. The initial literature search identified 517 studies. After screening the title, abstract, key words, and reference lists, 56 studies met the inclusion criteria. Results: The overall results revealed that increases in Aβ are related to lower hippocampal volume and worse performance on EM tests. The results of this systematic review revealed that high levels of Aβ may be related to EM deficits and the progression to Alzheimer’s disease. Conclusions: We discussed the strengths and pitfalls of various tests and techniques used for investigating EM and Aβ deposition, methodological issues, and potential directions for future research.

KW - Aging

KW - Beta amyloid

KW - Episodic

KW - Healthy aging

KW - Memory

KW - Systematic review

UR - http://www.scopus.com/inward/record.url?scp=85114485352&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/69379148-a881-3e93-96b9-887d33b0ad41/

U2 - 10.1590/1980-57642021dn15-030002

DO - 10.1590/1980-57642021dn15-030002

M3 - статья

C2 - 34630918

AN - SCOPUS:85114485352

VL - 15

SP - 299

EP - 313

JO - Dementia e Neuropsychologia

JF - Dementia e Neuropsychologia

SN - 1980-5764

IS - 3

ER -