TY - JOUR

T1 - Cytokines as mediators of neuroimmune interactions

AU - Grishina, T. V.

AU - Мюльберг, А. А.

PY - 2006/12/1

Y1 - 2006/12/1

N2 - Cytokines regulate numerous physiological and pathological processes in the central nervous system (CNS), i.e. they function both as immune regulators and neuromodulators. Acting upon the CNS via different ways, cytokines, mainly proinflammatory ones /L-1β and TNF-α, can disturb physiological functions of the CNS, cause neurotoxic and neurodegenerative damage and stimulate IL-1 βsynthesis in hypothalamus nuclei and posterior pituitary. They can produce stress-like effects upon the CNS and affect the activity of the axis hypothalamus - pituitary - adrenal glands, levels of neuropeptides in hypothalamic regions of brain, synthesis and utilization of central monoamines. These influences can implement the effects of sensitization, which enhances neuroendocrine responses to later stresses. Microglia and astrocytes, secondary messengers and interaction between hypothalamus and anterior pituitary play an important role in range of these processes as well as in the maintenance of Th1/Th2 cytokine balance.

AB - Cytokines regulate numerous physiological and pathological processes in the central nervous system (CNS), i.e. they function both as immune regulators and neuromodulators. Acting upon the CNS via different ways, cytokines, mainly proinflammatory ones /L-1β and TNF-α, can disturb physiological functions of the CNS, cause neurotoxic and neurodegenerative damage and stimulate IL-1 βsynthesis in hypothalamus nuclei and posterior pituitary. They can produce stress-like effects upon the CNS and affect the activity of the axis hypothalamus - pituitary - adrenal glands, levels of neuropeptides in hypothalamic regions of brain, synthesis and utilization of central monoamines. These influences can implement the effects of sensitization, which enhances neuroendocrine responses to later stresses. Microglia and astrocytes, secondary messengers and interaction between hypothalamus and anterior pituitary play an important role in range of these processes as well as in the maintenance of Th1/Th2 cytokine balance.

KW - нейроиммунные взаимодействия, цитокины, интерлейкин-1, фактор некроза опухоли, физиологические функции ЦНС, нейродегенерация, нейропротекция, нейроэндокринные эффекты, баланс Th1/Th2 цитокинов

UR - http://www.scopus.com/inward/record.url?scp=33645048478&partnerID=8YFLogxK

M3 - Article

C2 - 16522001

AN - SCOPUS:33645048478

VL - 37

SP - 25

EP - 27

JO - УСПЕХИ ФИЗИОЛОГИЧЕСКИХ НАУК

JF - УСПЕХИ ФИЗИОЛОГИЧЕСКИХ НАУК

SN - 0301-1798

IS - 1

ER -