Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli–Cushman Reaction of Unprotected Oximes

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Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli–Cushman Reaction of Unprotected Oximes. / Bakulina, Olga ; Bannykh, Anton ; Dar'in, Dmitry ; Krasavin, Mikhail.

в: Chemistry - A European Journal, Том 23, № 70, 14.12.2017, стр. 17667-17673.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

BibTeX

@article{efce1a14e93044a3b6acb2e604857689,

title = "Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli–Cushman Reaction of Unprotected Oximes",

abstract = "The first application of multicomponent chemistry (the Castagnoli–Cushman reaction) toward the convenient one-step preparation of cyclic hydroxamic acids is described. Cyclic hydroxamic acids are close analogues of bacterial siderophores (iron-binding compounds) and form stable complexes with Fe3+ ions as confirmed by spectrophotometric measurements. These compounds are potential components for the design of chelating agents for iron overload disease therapy, as well as siderophore-based carrier systems for antibiotic delivery across the bacterial cell wall.",

keywords = "Castagnoli–Cushman reaction, cyclic hydroxamic acids, homophthalic anhydride, iron chelation, multicomponent chemistry",

author = "Olga Bakulina and Anton Bannykh and Dmitry Dar'in and Mikhail Krasavin",

year = "2017",

month = dec,

day = "14",

doi = "10.1002/chem.201704389",

language = "English",

volume = "23",

pages = "17667--17673",

journal = "Chemistry - A European Journal",

issn = "0947-6539",

publisher = "Wiley-Blackwell",

number = "70",

}

RIS

TY - JOUR

T1 - Cyclic Hydroxamic Acid Analogues of Bacterial Siderophores as Iron-Complexing Agents prepared through the Castagnoli–Cushman Reaction of Unprotected Oximes

AU - Bakulina, Olga

AU - Bannykh, Anton

AU - Dar'in, Dmitry

AU - Krasavin, Mikhail

PY - 2017/12/14

Y1 - 2017/12/14

N2 - The first application of multicomponent chemistry (the Castagnoli–Cushman reaction) toward the convenient one-step preparation of cyclic hydroxamic acids is described. Cyclic hydroxamic acids are close analogues of bacterial siderophores (iron-binding compounds) and form stable complexes with Fe3+ ions as confirmed by spectrophotometric measurements. These compounds are potential components for the design of chelating agents for iron overload disease therapy, as well as siderophore-based carrier systems for antibiotic delivery across the bacterial cell wall.

AB - The first application of multicomponent chemistry (the Castagnoli–Cushman reaction) toward the convenient one-step preparation of cyclic hydroxamic acids is described. Cyclic hydroxamic acids are close analogues of bacterial siderophores (iron-binding compounds) and form stable complexes with Fe3+ ions as confirmed by spectrophotometric measurements. These compounds are potential components for the design of chelating agents for iron overload disease therapy, as well as siderophore-based carrier systems for antibiotic delivery across the bacterial cell wall.

KW - Castagnoli–Cushman reaction

KW - cyclic hydroxamic acids

KW - homophthalic anhydride

KW - iron chelation

KW - multicomponent chemistry

UR - http://www.scopus.com/inward/record.url?scp=85037974358&partnerID=8YFLogxK

U2 - 10.1002/chem.201704389

DO - 10.1002/chem.201704389

M3 - Article

C2 - 29072340

AN - SCOPUS:85037974358

VL - 23

SP - 17667

EP - 17673

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 70

ER -

ID: 34634714