Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Cyclic diazo compounds in the construction of spirocyclic scaffolds. / Solovyev, Igor; Eremeyeva, Maria; Zhukovsky, Daniil; Dar'in, Dmitry; Krasavin, Mikhail.
в: Tetrahedron Letters, 2020.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
}
TY - JOUR
T1 - Cyclic diazo compounds in the construction of spirocyclic scaffolds
AU - Solovyev, Igor
AU - Eremeyeva, Maria
AU - Zhukovsky, Daniil
AU - Dar'in, Dmitry
AU - Krasavin, Mikhail
N1 - Funding Information: This work was supported by the Russian Foundation for Basic Research (project grant 19-03-00775 ). Igor Solovyev is grateful to the Russian Foundation for Basic Research for his graduate student fellowship (project grant 19-33-90018). Publisher Copyright: © 2020 Elsevier Ltd Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Spirocycles represent an emerging class of privileged motifs for drug discovery. The versatility of diazo compounds in constructing cyclic frameworks in general makes cyclic diazo compounds a potentially highly prolific source of spirocyclic scaffolds. While the first examples of obtaining a spirocycle from a cyclic diazo compound are dated as far back as 42 years ago, there appears to be a resurgence of novel methodologies based on this premise. The present Digest Article aims to cover the literature on the subject to-date.
AB - Spirocycles represent an emerging class of privileged motifs for drug discovery. The versatility of diazo compounds in constructing cyclic frameworks in general makes cyclic diazo compounds a potentially highly prolific source of spirocyclic scaffolds. While the first examples of obtaining a spirocycle from a cyclic diazo compound are dated as far back as 42 years ago, there appears to be a resurgence of novel methodologies based on this premise. The present Digest Article aims to cover the literature on the subject to-date.
KW - Cyclization
KW - Diazo compounds
KW - Multiple reactivity modes
KW - Privileged structures for drug discovery
KW - Spirocyclic scaffolds
UR - http://www.scopus.com/inward/record.url?scp=85097458338&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/1f42eda9-f987-33f1-a157-66065eabb140/
U2 - 10.1016/j.tetlet.2020.152671
DO - 10.1016/j.tetlet.2020.152671
M3 - Review article
AN - SCOPUS:85097458338
JO - Tetrahedron Letters
JF - Tetrahedron Letters
SN - 0040-4039
M1 - 152671
ER -
ID: 71835592