TY - JOUR

T1 - Current State of Modeling Human Psychiatric Disorders Using Zebrafish

AU - Costa, Fabiano V.

AU - Kolesnikova , Tatiana O.

AU - Galstyan, David S.

AU - Ilyin , Nikita P.

AU - de Abreu, Murilo S

AU - Petersen , Elena V.

AU - Demin , Konstantin A.

AU - Yenkoyan, Konstantin B.

AU - Kalueff, Allan V.

N1 - Costa, F.V.; Kolesnikova, T.O.; Galstyan, D.S.; Ilyin, N.P.; de Abreu, M.S.; Petersen, E.V.; Demin, K.A.; Yenkoyan, K.B.; Kalueff, A.V. Current State of Modeling Human Psychiatric Disorders Using Zebrafish. Int. J. Mol. Sci. 2023, 24, 3187. https://doi.org/10.3390/ijms24043187

PY - 2023

Y1 - 2023

N2 - Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet biomedical problem. Since reliable clinical diagnoses are essential for the treatment of psychiatric disorders, their animal models with robust, relevant behavioral and physiological endpoints become necessary. Zebrafish (Danio rerio) display well-defined, complex behaviors in major neurobehavioral domains which are evolutionarily conserved and strikingly parallel to those seen in rodents and humans. Although zebrafish are increasingly often used to model psychiatric disorders, there are also multiple challenges with such models as well. The field may therefore benefit from a balanced, disease-oriented discussion that considers the clinical prevalence, the pathological complexity, and societal importance of the disorders in question, and the extent of its detalization in zebrafish central nervous system (CNS) studies. Here, we critically discuss the use of zebrafish for modeling human psychiatric disorders in general, and highlight the topics for further in-depth consideration, in order to foster and (re)focus translational biological neuroscience research utilizing zebrafish. Recent developments in molecular biology research utilizing this model species have also been summarized here, collectively calling for a wider use of zebrafish in translational CNS disease modeling.

AB - Psychiatric disorders are highly prevalent brain pathologies that represent an urgent, unmet biomedical problem. Since reliable clinical diagnoses are essential for the treatment of psychiatric disorders, their animal models with robust, relevant behavioral and physiological endpoints become necessary. Zebrafish (Danio rerio) display well-defined, complex behaviors in major neurobehavioral domains which are evolutionarily conserved and strikingly parallel to those seen in rodents and humans. Although zebrafish are increasingly often used to model psychiatric disorders, there are also multiple challenges with such models as well. The field may therefore benefit from a balanced, disease-oriented discussion that considers the clinical prevalence, the pathological complexity, and societal importance of the disorders in question, and the extent of its detalization in zebrafish central nervous system (CNS) studies. Here, we critically discuss the use of zebrafish for modeling human psychiatric disorders in general, and highlight the topics for further in-depth consideration, in order to foster and (re)focus translational biological neuroscience research utilizing zebrafish. Recent developments in molecular biology research utilizing this model species have also been summarized here, collectively calling for a wider use of zebrafish in translational CNS disease modeling.

KW - Danio rerio

KW - animal modelling

KW - translational biopsychiatry

KW - psychiatric disorders

UR - https://www.mdpi.com/1422-0067/24/4/3187

M3 - Article

VL - 24

JO - International Journal of Molecular Sciences

JF - International Journal of Molecular Sciences

SN - 1422-0067

IS - 4

M1 - 3187

ER -