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Cross-hemispheric dopamine projections have functional significance. / Fox, M. E.; Mikhailova, M. A.; Bass, C. E.; Takmakov, P.; Gainetdinov, R. R.; Budygin, E. A.; Wightman, R. M.

в: Proc Natl Acad Sci U S A, Том 113, № 25, 2016, стр. 6985-6990.

Результаты исследований: Научные публикации в периодических изданиях › статья

Harvard

Fox, ME, Mikhailova, MA, Bass, CE, Takmakov, P, Gainetdinov, RR, Budygin, EA & Wightman, RM 2016, 'Cross-hemispheric dopamine projections have functional significance', Proc Natl Acad Sci U S A, Том. 113, № 25, стр. 6985-6990. <https://www.ncbi.nlm.nih.gov/pubmed/27298371>

APA

Fox, M. E., Mikhailova, M. A., Bass, C. E., Takmakov, P., Gainetdinov, R. R., Budygin, E. A., & Wightman, R. M. (2016). Cross-hemispheric dopamine projections have functional significance. Proc Natl Acad Sci U S A, 113(25), 6985-6990. https://www.ncbi.nlm.nih.gov/pubmed/27298371

Vancouver

Fox ME, Mikhailova MA, Bass CE, Takmakov P, Gainetdinov RR, Budygin EA и пр. Cross-hemispheric dopamine projections have functional significance. Proc Natl Acad Sci U S A. 2016;113(25):6985-6990.

Author

Fox, M. E. ; Mikhailova, M. A. ; Bass, C. E. ; Takmakov, P. ; Gainetdinov, R. R. ; Budygin, E. A. ; Wightman, R. M. / Cross-hemispheric dopamine projections have functional significance. в: Proc Natl Acad Sci U S A. 2016 ; Том 113, № 25. стр. 6985-6990.

BibTeX

@article{6f9909613c074bd692f4d73e34fdb51a,
title = "Cross-hemispheric dopamine projections have functional significance",
abstract = "Dopamine signaling occurs on a subsecond timescale, and its dysregulation is implicated in pathologies ranging from drug addiction to Parkinson's disease. Anatomic evidence suggests that some dopamine neurons have cross-hemispheric projections, but the significance of these projections is unknown. Here we report unprecedented interhemispheric communication in the midbrain dopamine system of awake and anesthetized rats. In the anesthetized rats, optogenetic and electrical stimulation of dopamine cells elicited physiologically relevant dopamine release in the contralateral striatum. Contralateral release differed between the dorsal and ventral striatum owing to differential regulation by D2-like receptors. In the freely moving animals, simultaneous bilateral measurements revealed that dopamine release synchronizes between hemispheres and intact, contralateral projections can release dopamine in the midbrain of 6-hydroxydopamine-lesioned rats. These experiments are the first, to our knowledge, to show cross-hemi",
keywords = "dopamine, dorsal striatum, nucleus accumbens, synchrony, voltammetry",
author = "Fox, {M. E.} and Mikhailova, {M. A.} and Bass, {C. E.} and P. Takmakov and Gainetdinov, {R. R.} and Budygin, {E. A.} and Wightman, {R. M.}",
year = "2016",
language = "English",
volume = "113",
pages = "6985--6990",
journal = "Proceedings of the National Academy of Sciences of the United States of America",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "25",

}

RIS

TY - JOUR

T1 - Cross-hemispheric dopamine projections have functional significance

AU - Fox, M. E.

AU - Mikhailova, M. A.

AU - Bass, C. E.

AU - Takmakov, P.

AU - Gainetdinov, R. R.

AU - Budygin, E. A.

AU - Wightman, R. M.

PY - 2016

Y1 - 2016

N2 - Dopamine signaling occurs on a subsecond timescale, and its dysregulation is implicated in pathologies ranging from drug addiction to Parkinson's disease. Anatomic evidence suggests that some dopamine neurons have cross-hemispheric projections, but the significance of these projections is unknown. Here we report unprecedented interhemispheric communication in the midbrain dopamine system of awake and anesthetized rats. In the anesthetized rats, optogenetic and electrical stimulation of dopamine cells elicited physiologically relevant dopamine release in the contralateral striatum. Contralateral release differed between the dorsal and ventral striatum owing to differential regulation by D2-like receptors. In the freely moving animals, simultaneous bilateral measurements revealed that dopamine release synchronizes between hemispheres and intact, contralateral projections can release dopamine in the midbrain of 6-hydroxydopamine-lesioned rats. These experiments are the first, to our knowledge, to show cross-hemi

AB - Dopamine signaling occurs on a subsecond timescale, and its dysregulation is implicated in pathologies ranging from drug addiction to Parkinson's disease. Anatomic evidence suggests that some dopamine neurons have cross-hemispheric projections, but the significance of these projections is unknown. Here we report unprecedented interhemispheric communication in the midbrain dopamine system of awake and anesthetized rats. In the anesthetized rats, optogenetic and electrical stimulation of dopamine cells elicited physiologically relevant dopamine release in the contralateral striatum. Contralateral release differed between the dorsal and ventral striatum owing to differential regulation by D2-like receptors. In the freely moving animals, simultaneous bilateral measurements revealed that dopamine release synchronizes between hemispheres and intact, contralateral projections can release dopamine in the midbrain of 6-hydroxydopamine-lesioned rats. These experiments are the first, to our knowledge, to show cross-hemi

KW - dopamine

KW - dorsal striatum

KW - nucleus accumbens

KW - synchrony

KW - voltammetry

M3 - Article

VL - 113

SP - 6985

EP - 6990

JO - Proceedings of the National Academy of Sciences of the United States of America

JF - Proceedings of the National Academy of Sciences of the United States of America

SN - 0027-8424

IS - 25

ER -

ID: 7599117