Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Correlation between the bone mass of athletes and biochemical and genetic markers of bone tissue remodeling. / Oganov, V. S.; Vinogradova, O. L.; Dudov, N. S.; Baranov, V. S.; Minenkov, A. S.; Bakulin, A. V.; Novikov, V. E.; Kabitskaya, O. E.; Moskalenko, M. V.; Glotov, A. S.; Glotov, O. S.; Popov, D. V.
в: Human Physiology, Том 34, № 2, 03.2008, стр. 182-190.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Correlation between the bone mass of athletes and biochemical and genetic markers of bone tissue remodeling
AU - Oganov, V. S.
AU - Vinogradova, O. L.
AU - Dudov, N. S.
AU - Baranov, V. S.
AU - Minenkov, A. S.
AU - Bakulin, A. V.
AU - Novikov, V. E.
AU - Kabitskaya, O. E.
AU - Moskalenko, M. V.
AU - Glotov, A. S.
AU - Glotov, O. S.
AU - Popov, D. V.
N1 - Funding Information: ACKNOWLEDGMENTS This study was partly supported by the Russian Foundation for Basic Research, project no. 05-04-49362a.
PY - 2008/3
Y1 - 2008/3
N2 - The association of the polymorphism of the VDR, Col1a1, and CALCR genes with a form of osteoporosis frequently occurring as a consequence of intense physical exercise in athletes was studied. Biochemical parameters of bone remodeling and its neuroendocrine regulation, as well as the bone masses, of 22 amateur athletes were determined immediately before a strenuous nine-week training cycle (TC) and eight months later. The possible association of these factors with the polymorphism of the genes coding for bone tissue proteins was studied. Long-term intense physical training was found to be associated with a significant activation of bone tissue resorption accompanied by continued rapid synthesis. Nevertheless, and in spite of the strong activation of resorption caused by the TC, the athletes exhibited no osteoporosis (even eight months after the discontinuation of the TC); some of them, however, displayed an individual tendency to osteopenia. According to the results of genetic analysis, this was associated with the polymorphism of predisposition genes (genotype TT of the VDR gene and the functionally weakened s allele of the Col1a1 gene).
AB - The association of the polymorphism of the VDR, Col1a1, and CALCR genes with a form of osteoporosis frequently occurring as a consequence of intense physical exercise in athletes was studied. Biochemical parameters of bone remodeling and its neuroendocrine regulation, as well as the bone masses, of 22 amateur athletes were determined immediately before a strenuous nine-week training cycle (TC) and eight months later. The possible association of these factors with the polymorphism of the genes coding for bone tissue proteins was studied. Long-term intense physical training was found to be associated with a significant activation of bone tissue resorption accompanied by continued rapid synthesis. Nevertheless, and in spite of the strong activation of resorption caused by the TC, the athletes exhibited no osteoporosis (even eight months after the discontinuation of the TC); some of them, however, displayed an individual tendency to osteopenia. According to the results of genetic analysis, this was associated with the polymorphism of predisposition genes (genotype TT of the VDR gene and the functionally weakened s allele of the Col1a1 gene).
UR - http://www.scopus.com/inward/record.url?scp=43149112780&partnerID=8YFLogxK
U2 - 10.1134/S0362119708020072
DO - 10.1134/S0362119708020072
M3 - Article
AN - SCOPUS:43149112780
VL - 34
SP - 182
EP - 190
JO - Human Physiology
JF - Human Physiology
SN - 0362-1197
IS - 2
ER -
ID: 101229079