TY - JOUR

T1 - CORRECTION OF RENAL FUNCTION BY DESMOPRESSINAND DICLOFENAC IN INCONTINENT WOMEN WITH NOCTURIA

AU - Джемлиханова, Ляиля Харрясовна

AU - Ниаури, Дарико Александровна

AU - Осипова, Наталья Анатольевна

AU - Гзгзян, Александр Мкртичевич

PY - 2017

Y1 - 2017

N2 - The purpose of this study was to evaluate the clinical efficiency of desmopressine and diclofenac in in-continent patients with nocturnal polyuria and polyuria. A total of 277 patients ≥18 ≤ 55 years of age with complaints of urinary incontinence were included. 143 women had stress incontinence, 43 — urge incontinence and 91 — mixed incontinence. The overall prevalence of nocturia was 34.7 ± 2.9% (96 wo-men). The frequency of poliuriya was 7 ± 2.1 % in stress incontinence, 11.6 ± 4.9 % in urge incon-tinence and 9.9 ± 3.1 % in mixed incontinence (p > 0.05). The frequency of nocturnal polyuria was 17.5 ± 3.2% in stress incontinence, 27.9 ± 6.8% in urge incontinence and 25.3 ± 4.6 % mixed incon-tinence (p > 0.05). Patients were randomized to receive either desmopressin or diclofenac in a dou-ble — blind fashion. The statistically significant recovery of renal function occurred in 8 incontinent women with polyuria and 19 with nocturnal polyuria who received diclofenac and in 12 incontinent women with polyuria and 18 with nocturnal polyuria who received desmopressin (Minirin).

AB - The purpose of this study was to evaluate the clinical efficiency of desmopressine and diclofenac in in-continent patients with nocturnal polyuria and polyuria. A total of 277 patients ≥18 ≤ 55 years of age with complaints of urinary incontinence were included. 143 women had stress incontinence, 43 — urge incontinence and 91 — mixed incontinence. The overall prevalence of nocturia was 34.7 ± 2.9% (96 wo-men). The frequency of poliuriya was 7 ± 2.1 % in stress incontinence, 11.6 ± 4.9 % in urge incon-tinence and 9.9 ± 3.1 % in mixed incontinence (p > 0.05). The frequency of nocturnal polyuria was 17.5 ± 3.2% in stress incontinence, 27.9 ± 6.8% in urge incontinence and 25.3 ± 4.6 % mixed incon-tinence (p > 0.05). Patients were randomized to receive either desmopressin or diclofenac in a dou-ble — blind fashion. The statistically significant recovery of renal function occurred in 8 incontinent women with polyuria and 19 with nocturnal polyuria who received diclofenac and in 12 incontinent women with polyuria and 18 with nocturnal polyuria who received desmopressin (Minirin).

KW - renal osmoregulatoin function, incontinence, sodium excretion, desmopressin, diclofenaс

M3 - Article

VL - 12

SP - 161

EP - 169

JO - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

JF - ВЕСТНИК САНКТ-ПЕТЕРБУРГСКОГО УНИВЕРСИТЕТА. МЕДИЦИНА

SN - 1818-2909

IS - 2

M1 - DOI: 10.21638/11701/spbu11.2017.205

ER -