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Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides. / Geyl, Kirill; Baykov, Sergey; Tarasenko, Marina; Zelenkov, Lev E.; Matveevskaya, Vladislava; Boyarskiy, Vadim P.

в: Tetrahedron Letters, Том 60, № 40, 151108, 03.10.2019.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Geyl, K, Baykov, S, Tarasenko, M, Zelenkov, LE, Matveevskaya, V & Boyarskiy, VP 2019, 'Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides', Tetrahedron Letters, Том. 60, № 40, 151108. https://doi.org/10.1016/j.tetlet.2019.151108

APA

Geyl, K., Baykov, S., Tarasenko, M., Zelenkov, L. E., Matveevskaya, V., & Boyarskiy, V. P. (2019). Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides. Tetrahedron Letters, 60(40), [151108]. https://doi.org/10.1016/j.tetlet.2019.151108

Vancouver

Geyl K, Baykov S, Tarasenko M, Zelenkov LE, Matveevskaya V, Boyarskiy VP. Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides. Tetrahedron Letters. 2019 Окт. 3;60(40). 151108. https://doi.org/10.1016/j.tetlet.2019.151108

Author

Geyl, Kirill ; Baykov, Sergey ; Tarasenko, Marina ; Zelenkov, Lev E. ; Matveevskaya, Vladislava ; Boyarskiy, Vadim P. / Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides. в: Tetrahedron Letters. 2019 ; Том 60, № 40.

BibTeX

@article{75cafa240a734d50b2b3584ee0000c21,
title = "Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides",
abstract = "Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C[sbnd]H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “lead-like” scaffolds for medicinal chemistry. Atom-economy, environmental friendliness (no halide-containing or toxic reagents), simple work-up, as well as scalability are the main advantages of the employed procedure.",
keywords = "C[sbnd]H activation, Dialkylcyanamides, N-Oxides, Ureas, Diastereoselective, Enantioselective, Tamura reaction, Organocatalysis, Vinylidene indanedione",
author = "Kirill Geyl and Sergey Baykov and Marina Tarasenko and Zelenkov, {Lev E.} and Vladislava Matveevskaya and Boyarskiy, {Vadim P.}",
note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = oct,
day = "3",
doi = "10.1016/j.tetlet.2019.151108",
language = "English",
volume = "60",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier",
number = "40",

}

RIS

TY - JOUR

T1 - Convenient entry to N-pyridinylureas with pharmaceutically privileged oxadiazole substituents via the acid-catalyzed C[sbnd]H activation of N-oxides

AU - Geyl, Kirill

AU - Baykov, Sergey

AU - Tarasenko, Marina

AU - Zelenkov, Lev E.

AU - Matveevskaya, Vladislava

AU - Boyarskiy, Vadim P.

N1 - Publisher Copyright: © 2019 Elsevier Ltd

PY - 2019/10/3

Y1 - 2019/10/3

N2 - Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C[sbnd]H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “lead-like” scaffolds for medicinal chemistry. Atom-economy, environmental friendliness (no halide-containing or toxic reagents), simple work-up, as well as scalability are the main advantages of the employed procedure.

AB - Pyridine-N-oxides bearing a pharmacophoric oxadiazole moiety could be C[sbnd]H functionalized via the acid-catalyzed reaction with dialkylcyanamides, providing access to hitherto undescribed pyridine-2-yl substituted ureas, which have potential as “lead-like” scaffolds for medicinal chemistry. Atom-economy, environmental friendliness (no halide-containing or toxic reagents), simple work-up, as well as scalability are the main advantages of the employed procedure.

KW - C[sbnd]H activation

KW - Dialkylcyanamides

KW - N-Oxides

KW - Ureas

KW - Diastereoselective

KW - Enantioselective

KW - Tamura reaction

KW - Organocatalysis

KW - Vinylidene indanedione

UR - http://www.scopus.com/inward/record.url?scp=85071979075&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2019.151108

DO - 10.1016/j.tetlet.2019.151108

M3 - Article

AN - SCOPUS:85071979075

VL - 60

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 40

M1 - 151108

ER -

ID: 46202162