Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis. / Zotova, Irina; Stepchenkova, Elena; Pavlov, Youri.
в: Biological Communications, Том 64, № 2, 2019, стр. 110-123.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Contribution of cytosine desaminases of AID/APOBEC family to carcinogenesis.
AU - Zotova, Irina
AU - Stepchenkova, Elena
AU - Pavlov, Youri
PY - 2019
Y1 - 2019
N2 - Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become “weapons of mass destruction,” causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism’s defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.
AB - Cytosine deaminases of the AID/APOBEC family have a weighty influence on human health. These enzymes are part of the innate and humoral immunity; they participate in lipid metabolism and muscle development, protect cells from viruses and regulate retrotransposition. If the activity of AID/APOBEC deaminases is misregulated, they can become “weapons of mass destruction,” causing deaminations in unprotected single-stranded DNA regions leading to genome-wide mutagenesis. Ultimately, mutations contribute to cell malignancy and rapid evolution of cancer cells, helping them to evade the organism’s defense. Also, hypermutable tumor cells develop resistance to anti-cancer drugs. Here we overview current understanding of the structure, functions, and regulation of AID/APOBEC cytosine deaminases in connection to carcinogenesis.
KW - cancer
KW - Cytosine deaminases AID/APOBEC
KW - DNA damage
KW - mutation
KW - cancer
KW - Cytosine deaminases AID/APOBEC
KW - DNA damage
KW - mutation
M3 - Article
VL - 64
SP - 110
EP - 123
JO - Biological Communications
JF - Biological Communications
SN - 2542-2154
IS - 2
ER -
ID: 78403405