Standard

Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists. / Krasavin, Mikhail; Lukin, Alexei; Bakholdina, Anna; Zhurilo, Nikolay; Onopchenko, Oleksandra; Borysko, Petro; Zozulya, Sergey; Moore, Daniel; Tikhonova, Irina G.

в: European Journal of Medicinal Chemistry, Том 140, 01.01.2017, стр. 229-238.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Krasavin, M, Lukin, A, Bakholdina, A, Zhurilo, N, Onopchenko, O, Borysko, P, Zozulya, S, Moore, D & Tikhonova, IG 2017, 'Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists', European Journal of Medicinal Chemistry, Том. 140, стр. 229-238. https://doi.org/10.1016/j.ejmech.2017.09.019

APA

Krasavin, M., Lukin, A., Bakholdina, A., Zhurilo, N., Onopchenko, O., Borysko, P., Zozulya, S., Moore, D., & Tikhonova, I. G. (2017). Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists. European Journal of Medicinal Chemistry, 140, 229-238. https://doi.org/10.1016/j.ejmech.2017.09.019

Vancouver

Krasavin M, Lukin A, Bakholdina A, Zhurilo N, Onopchenko O, Borysko P и пр. Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists. European Journal of Medicinal Chemistry. 2017 Янв. 1;140:229-238. https://doi.org/10.1016/j.ejmech.2017.09.019

Author

Krasavin, Mikhail ; Lukin, Alexei ; Bakholdina, Anna ; Zhurilo, Nikolay ; Onopchenko, Oleksandra ; Borysko, Petro ; Zozulya, Sergey ; Moore, Daniel ; Tikhonova, Irina G. / Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists. в: European Journal of Medicinal Chemistry. 2017 ; Том 140. стр. 229-238.

BibTeX

@article{117adfc78ee24cea9f6e2d399517ae7e,
title = "Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists",
abstract = "An earlier reported series of 1,2,4-thiadiazole-based agonists of FFA1 (GPR40) was evolved into two structurally distinct series of compounds. One of the series (structurally related to known FFA1 agonist GW9508) displayed low micromolar potency while the other (representing a truncated version of the earlier reported potent FFA1 agonists) was, surprisingly, found to be devoid of agonist potency. In silico docking of representative compounds into the crystal structure of FFA1 revealed possible structural grounds for the observed SAR.",
keywords = "1,2,4-Thiadiazole, Agonist potency, Free fatty acid receptor 1, GPR40, Heterocyclic bioisosteres, In silico docking",
author = "Mikhail Krasavin and Alexei Lukin and Anna Bakholdina and Nikolay Zhurilo and Oleksandra Onopchenko and Petro Borysko and Sergey Zozulya and Daniel Moore and Tikhonova, {Irina G.}",
year = "2017",
month = jan,
day = "1",
doi = "10.1016/j.ejmech.2017.09.019",
language = "English",
volume = "140",
pages = "229--238",
journal = "European Journal of Medicinal Chemistry",
issn = "0223-5234",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Continued SAR exploration of 1,2,4-thiadiazole-containing scaffolds in the design of free fatty acid receptor 1 (GPR40) agonists

AU - Krasavin, Mikhail

AU - Lukin, Alexei

AU - Bakholdina, Anna

AU - Zhurilo, Nikolay

AU - Onopchenko, Oleksandra

AU - Borysko, Petro

AU - Zozulya, Sergey

AU - Moore, Daniel

AU - Tikhonova, Irina G.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - An earlier reported series of 1,2,4-thiadiazole-based agonists of FFA1 (GPR40) was evolved into two structurally distinct series of compounds. One of the series (structurally related to known FFA1 agonist GW9508) displayed low micromolar potency while the other (representing a truncated version of the earlier reported potent FFA1 agonists) was, surprisingly, found to be devoid of agonist potency. In silico docking of representative compounds into the crystal structure of FFA1 revealed possible structural grounds for the observed SAR.

AB - An earlier reported series of 1,2,4-thiadiazole-based agonists of FFA1 (GPR40) was evolved into two structurally distinct series of compounds. One of the series (structurally related to known FFA1 agonist GW9508) displayed low micromolar potency while the other (representing a truncated version of the earlier reported potent FFA1 agonists) was, surprisingly, found to be devoid of agonist potency. In silico docking of representative compounds into the crystal structure of FFA1 revealed possible structural grounds for the observed SAR.

KW - 1,2,4-Thiadiazole

KW - Agonist potency

KW - Free fatty acid receptor 1

KW - GPR40

KW - Heterocyclic bioisosteres

KW - In silico docking

UR - http://www.scopus.com/inward/record.url?scp=85029547304&partnerID=8YFLogxK

U2 - 10.1016/j.ejmech.2017.09.019

DO - 10.1016/j.ejmech.2017.09.019

M3 - Article

C2 - 28938138

AN - SCOPUS:85029547304

VL - 140

SP - 229

EP - 238

JO - European Journal of Medicinal Chemistry

JF - European Journal of Medicinal Chemistry

SN - 0223-5234

ER -

ID: 34635354