Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics. / Capogrosso, Marco; Wagner, Fabien B.; Gandar, Jerome; Moraud, Eduardo Martin; Wenger, Nikolaus; Milekovic, Tomislav; Shkorbatova, Polina; Pavlova, Natalia; Musienko, Pavel; Bezard, Erwan; Bloch, Jocelyne; Courtine, Grégoire.
в: Nature Protocols, Том 13, № 9, 01.09.2018, стр. 2031-2061.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Configuration of electrical spinal cord stimulation through real-time processing of gait kinematics
AU - Capogrosso, Marco
AU - Wagner, Fabien B.
AU - Gandar, Jerome
AU - Moraud, Eduardo Martin
AU - Wenger, Nikolaus
AU - Milekovic, Tomislav
AU - Shkorbatova, Polina
AU - Pavlova, Natalia
AU - Musienko, Pavel
AU - Bezard, Erwan
AU - Bloch, Jocelyne
AU - Courtine, Grégoire
PY - 2018/9/1
Y1 - 2018/9/1
N2 - Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted spinal cord stimulation systems that remain stable up to several months after implantation in rats and nonhuman primates. We also detail how to exploit these implants to configure electrical spinal cord stimulation policies that allow control over the degree of extension and flexion of each leg during locomotion. This protocol uses real-time processing of gait kinematics and locomotor performance, and can be configured within a few days. Once configured, stimulation bursts are delivered over specific spinal cord locations with precise timing that reproduces the natural spatiotemporal activation of motoneurons during locomotion. These protocols can also be easily adapted for the safe implantation of systems in the vicinity of the spinal cord and to conduct experiments involving real-time movement feedback and closed-loop controllers.
AB - Epidural electrical stimulation (EES) of the spinal cord and real-time processing of gait kinematics are powerful methods for the study of locomotion and the improvement of motor control after injury or in neurological disorders. Here, we describe equipment and surgical procedures that can be used to acquire chronic electromyographic (EMG) recordings from leg muscles and to implant targeted spinal cord stimulation systems that remain stable up to several months after implantation in rats and nonhuman primates. We also detail how to exploit these implants to configure electrical spinal cord stimulation policies that allow control over the degree of extension and flexion of each leg during locomotion. This protocol uses real-time processing of gait kinematics and locomotor performance, and can be configured within a few days. Once configured, stimulation bursts are delivered over specific spinal cord locations with precise timing that reproduces the natural spatiotemporal activation of motoneurons during locomotion. These protocols can also be easily adapted for the safe implantation of systems in the vicinity of the spinal cord and to conduct experiments involving real-time movement feedback and closed-loop controllers.
UR - http://www.scopus.com/inward/record.url?scp=85053309838&partnerID=8YFLogxK
U2 - 10.1038/s41596-018-0030-9
DO - 10.1038/s41596-018-0030-9
M3 - Article
C2 - 30190556
AN - SCOPUS:85053309838
VL - 13
SP - 2031
EP - 2061
JO - Nature Protocols
JF - Nature Protocols
SN - 1754-2189
IS - 9
ER -
ID: 49556017