Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy. / Shoenfeld, Yehuda; Rabkova, Varvara; Scheibenbogen, Carmen ; Brinth, Louise ; Martinez-Lavin, Manuel ; Ikeda, Shuichi ; Heidecke, Harald ; Watad, Abdulla ; Bragazzi, Nicola L.; Chapman, Joab ; Churilov, Leonid P.; Amital, Howard .
в: Clinical Immunology, Том 214, 108384, 05.2020.Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование
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TY - JOUR
T1 - Complex syndromes of chronic pain, fatigue and cognitive impairment linked to autoimmune dysautonomia and small fiber neuropathy
AU - Shoenfeld, Yehuda
AU - Rabkova, Varvara
AU - Scheibenbogen, Carmen
AU - Brinth, Louise
AU - Martinez-Lavin, Manuel
AU - Ikeda, Shuichi
AU - Heidecke, Harald
AU - Watad, Abdulla
AU - Bragazzi, Nicola L.
AU - Chapman, Joab
AU - Churilov, Leonid P.
AU - Amital, Howard
N1 - Publisher Copyright: © 2020 Elsevier Inc. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/5
Y1 - 2020/5
N2 - Abstract Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome and silicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both the pathogenesis and treatment of these disorders require further study. In this paper we summarize the evidence regarding the role of autoimmunity in these four syndromes with respect to immunogenetics, autoimmune co-morbidities, alteration in immune cell subsets, production of autoantibodies and presentation in animal models. These syndromes could be incorporated in a new concept of autoimmune neurosensory dysautonomia with the common denominators of autoantibodies against G-protein coupled receptors and small fiber neuropathy. Sjogren's syndrome, which is a classical autoimmune disease, could serve as a disease model, illustrating the concept. Development of this concept aims to identify an apparently autoimmune subgroup of the disputable disorders, addressed in the review, which may most benefit from the immunotherapy.
AB - Abstract Chronic fatigue syndrome, postural orthostatic tachycardia syndrome, complex regional pain syndrome and silicone implant incompatibility syndrome are a subject of debate among clinicians and researchers. Both the pathogenesis and treatment of these disorders require further study. In this paper we summarize the evidence regarding the role of autoimmunity in these four syndromes with respect to immunogenetics, autoimmune co-morbidities, alteration in immune cell subsets, production of autoantibodies and presentation in animal models. These syndromes could be incorporated in a new concept of autoimmune neurosensory dysautonomia with the common denominators of autoantibodies against G-protein coupled receptors and small fiber neuropathy. Sjogren's syndrome, which is a classical autoimmune disease, could serve as a disease model, illustrating the concept. Development of this concept aims to identify an apparently autoimmune subgroup of the disputable disorders, addressed in the review, which may most benefit from the immunotherapy.
KW - Chronic fatigue syndrome
KW - Complex regional pain syndrome
KW - Postural orthostatic tachycardia syndrome
KW - Autoantibodies
KW - Smallfiber neuropathy
KW - Silicone breast implants
KW - Small fiber neuropathy
UR - http://www.scopus.com/inward/record.url?scp=85081694192&partnerID=8YFLogxK
U2 - 10.1016/j.clim.2020.108384
DO - 10.1016/j.clim.2020.108384
M3 - Review article
VL - 214
JO - Clinical Immunology
JF - Clinical Immunology
SN - 1521-6616
M1 - 108384
ER -
ID: 52393410