Staphylothermus hellenicus belongs to the order Desulfurococcales within the archaeal phy-lum Crenarchaeota. Strain P8T is the type strain of the species and was isolated from a shal-low hydrothermal vent system at Palaeochori Bay, Milos, Greece. It is a hyperthermophilic, anaerobic heterotroph. Here we describe the features of this organism together with the com-plete genome sequence and annotation. The 1,580,347 bp genome with its 1,668 protein-coding and 48 RNA genes was sequenced as part of a DOE Joint Genome Institute (JGI) La-boratory Sequencing Program (LSP) project.