Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Comparative genomic analysis of Holospora spp., intranuclear symbionts of paramecia. / Garushyants, Sofya K.; Beliavskaia, Alexandra Y.; Malko, Dmitry B.; Logacheva, Maria D.; Rautian, Maria S.; Gelfand, Mikhail S.
в: Frontiers in Microbiology, Том 9, № APR, 738, 16.04.2018, стр. 738.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Comparative genomic analysis of Holospora spp., intranuclear symbionts of paramecia
AU - Garushyants, Sofya K.
AU - Beliavskaia, Alexandra Y.
AU - Malko, Dmitry B.
AU - Logacheva, Maria D.
AU - Rautian, Maria S.
AU - Gelfand, Mikhail S.
PY - 2018/4/16
Y1 - 2018/4/16
N2 - While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora curviuscula, a macronuclear symbiont of Paramecium bursaria, and known genomes of other Holospora species shows that even though all Holospora spp. can persist outside the host, they cannot synthesize most of the essential small molecules, such as amino acids, and lack some central energy metabolic pathways, including glycolysis and the citric acid cycle. As the main energy source, Holospora spp. likely rely on nucleotides pirated from the host. Holospora-specific genes absent from other Rickettsiales are possibly involved in the lifestyle switch from the infectious to the reproductive form and in cell invasion.
AB - While most endosymbiotic bacteria are transmitted only vertically, Holospora spp., an alphaproteobacterium from the Rickettsiales order, can desert its host and invade a new one. All bacteria from the genus Holospora are intranuclear symbionts of ciliates Paramecium spp. with strict species and nuclear specificity. Comparative metabolic reconstruction based on the newly sequenced genome of Holospora curviuscula, a macronuclear symbiont of Paramecium bursaria, and known genomes of other Holospora species shows that even though all Holospora spp. can persist outside the host, they cannot synthesize most of the essential small molecules, such as amino acids, and lack some central energy metabolic pathways, including glycolysis and the citric acid cycle. As the main energy source, Holospora spp. likely rely on nucleotides pirated from the host. Holospora-specific genes absent from other Rickettsiales are possibly involved in the lifestyle switch from the infectious to the reproductive form and in cell invasion.
KW - Ciliates
KW - Endosymbionts
KW - Genome
KW - Holospora
KW - Nuclear symbionts
KW - Paramecia
KW - Rickettsiales
KW - endosymbionts
KW - ciliates
KW - IDENTIFICATION
KW - nuclear symbionts
KW - genome
KW - PERIPLASMIC PROTEIN
KW - EVOLUTION
KW - INFECTION PROCESS
KW - CAUDATUM
KW - DATABASE
KW - ELEGANS
KW - FREE-LIVING BACTERIA
KW - INSECTS
KW - OBTUSA
KW - paramecia
UR - http://www.scopus.com/inward/record.url?scp=85045765981&partnerID=8YFLogxK
U2 - 10.3389/fmicb.2018.00738
DO - 10.3389/fmicb.2018.00738
M3 - Article
C2 - 29713316
AN - SCOPUS:85045765981
VL - 9
SP - 738
JO - Frontiers in Microbiology
JF - Frontiers in Microbiology
SN - 1664-302X
IS - APR
M1 - 738
ER -
ID: 36065706