Результаты исследований: Научные публикации в периодических изданиях › статья
Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication. / Montague, M.J.; Li, G.; Golfi, B.; Khan, R.; Aken, B.L.; Searle, S.M.J.; Minx, P.; Hillier, L.W.; Koboldt, D.C.; Davis, B.W.; Driscoll, C.A.; Barr, C.S.; Blackistone, K.; Quilez, J.; Lorente-Galdos, B.; Marques-Bonet, T.; Alkan, C.; Thomas, G.W.C.; Hahn, M.W.; Menotti-Raymond, M.; O'Brien, S.J.; Wilson, R.K.; Lyons, L.A.; Murphy, W.J.; Warren, W.C.
в: Proceedings of the National Academy of Sciences of the United States of America, № 48, 2014, стр. 17230-17235.Результаты исследований: Научные публикации в периодических изданиях › статья
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TY - JOUR
T1 - Comparative analysis of the domestic cat genome reveals genetic signatures underlying feline biology and domestication
AU - Montague, M.J.
AU - Li, G.
AU - Golfi, B.
AU - Khan, R.
AU - Aken, B.L.
AU - Searle, S.M.J.
AU - Minx, P.
AU - Hillier, L.W.
AU - Koboldt, D.C.
AU - Davis, B.W.
AU - Driscoll, C.A.
AU - Barr, C.S.
AU - Blackistone, K.
AU - Quilez, J.
AU - Lorente-Galdos, B.
AU - Marques-Bonet, T.
AU - Alkan, C.
AU - Thomas, G.W.C.
AU - Hahn, M.W.
AU - Menotti-Raymond, M.
AU - O'Brien, S.J.
AU - Wilson, R.K.
AU - Lyons, L.A.
AU - Murphy, W.J.
AU - Warren, W.C.
PY - 2014
Y1 - 2014
N2 - Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underlying sensory processes, especially those affecting vision and hearing in the carnivore lineage. We observed an evolutionary tradeoff between functional olfactory and vomeronasal receptor gene repertoires in the cat and dog genomes, with an expansion of the feline chemosensory system for detecting pheromones at the expense of odorant detection. Genomic regions harboring signatures of natural selection that distinguish domestic cats from their wild congeners are enriched in neural crest-related genes associated with beha
AB - Little is known about the genetic changes that distinguish domestic cat populations from their wild progenitors. Here we describe a high-quality domestic cat reference genome assembly and comparative inferences made with other cat breeds, wildcats, and other mammals. Based upon these comparisons, we identified positively selected genes enriched for genes involved in lipid metabolism that underpin adaptations to a hypercarnivorous diet. We also found positive selection signals within genes underlying sensory processes, especially those affecting vision and hearing in the carnivore lineage. We observed an evolutionary tradeoff between functional olfactory and vomeronasal receptor gene repertoires in the cat and dog genomes, with an expansion of the feline chemosensory system for detecting pheromones at the expense of odorant detection. Genomic regions harboring signatures of natural selection that distinguish domestic cats from their wild congeners are enriched in neural crest-related genes associated with beha
U2 - 10.1073/pnas.1410083111
DO - 10.1073/pnas.1410083111
M3 - Article
SP - 17230
EP - 17235
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
SN - 0027-8424
IS - 48
ER -
ID: 7065806