TY - JOUR

T1 - Cis-Isomers of Photosensitive Cationic Azobenzene Surfactants in DNA Solutions at Different NaCl Concentrations: Experiment and Modeling

AU - Silanteva, Irina A.

AU - Komolkin, Andrei V.

AU - Mamontova, Veronika V.

AU - Gabrusenok, Pavel V.

AU - Vorontsov-Velyaminov, Pavel N.

AU - Santer, Svetlana

AU - Kasyanenko, Nina A.

PY - 2021/10/14

Y1 - 2021/10/14

N2 - The DNA interaction with cis-isomers of photosensitive azobenzene-containing surfactants was studied by both experimental methods and computer simulation. It was shown that before the organization of micelles, such surfactants in the cis-conformation form associates of only a single type with a disordered orientation of molecules. In contrast, for trans-isomers, there exist two types of associates with head-to-head or head-to-tail orientations of molecules in dependence on salt concentration in a solution. The comparison of cis- and trans-isomer binding to DNA and the influence of salt concentration on the formation of their complexes with DNA were studied. It was shown that cis-isomers interact with phosphate groups of DNA and that their molecules were also located along the minor groove of DNA.

AB - The DNA interaction with cis-isomers of photosensitive azobenzene-containing surfactants was studied by both experimental methods and computer simulation. It was shown that before the organization of micelles, such surfactants in the cis-conformation form associates of only a single type with a disordered orientation of molecules. In contrast, for trans-isomers, there exist two types of associates with head-to-head or head-to-tail orientations of molecules in dependence on salt concentration in a solution. The comparison of cis- and trans-isomer binding to DNA and the influence of salt concentration on the formation of their complexes with DNA were studied. It was shown that cis-isomers interact with phosphate groups of DNA and that their molecules were also located along the minor groove of DNA.

UR - https://pubs.acs.org/doi/abs/10.1021/acs.jpcb.1c07864

UR - http://www.scopus.com/inward/record.url?scp=85117412277&partnerID=8YFLogxK

U2 - 10.1021/acs.jpcb.1c07864

DO - 10.1021/acs.jpcb.1c07864

M3 - Article

VL - 125

SP - 11197

EP - 11207

JO - Journal of Physical Chemistry B

JF - Journal of Physical Chemistry B

SN - 1520-6106

IS - 40

ER -