The expediency of developing new sorption and extraction methods of separation of substances has been proved based on the differences in their interfacial distribution and the principles of improving the methods of performing processes of interphase distribution. The possibility of implementing the idea of twodimensional chromatography is considered based on the methodology chromatomembrane mass transfer process. The schemes of the continuous extraction-chromatographic liberation of gold, platinum (IV), and palladium (II) are described with simultaneous separation from the impurities of base metals.