TY - JOUR

T1 - Cerebrospinal fluid of newly diagnosed amyotrophic lateral sclerosis patients exhibits abnormal levels of selenium species including elevated selenite

AU - Vinceti, M.

AU - Solovyev, N.

AU - Mandrioli, J.

AU - Crespi, C.M.

AU - Bonvicini, F.

AU - Arcolin, E.

AU - Georgoulopoulou, E.

AU - Michalke, B.

PY - 2013

Y1 - 2013

N2 - Exposure to selenium, and particularly to its inorganic forms, has been hypothesized as a risk factor for amyotrophic lateral sclerosis (ALS), a fast progressing motor neuron disease with poorly understood etiology. However, no information is known about levels of inorganic and some organic selenium species in the central nervous system of ALS patients, and recent observations suggest that peripheral biomarkers of exposure are unable to predict these levels for several Se species including the inorganic forms. Using a hospital-referred case–control series and advanced selenium speciation methods, we compared the chemical species of selenium in cerebrospinal fluid from 38 ALS patients to those of 38 reference neurological patients matched on age and gender. We found that higher concentrations of inorganic selenium in the form of selenite and of human serum albumin-bound selenium were associated with increased ALS risk (relative risks 3.9 (95% confidence interval 1.2–11.0) and 1.7 (1.0–2.9) for 0.1 μg/L increas

AB - Exposure to selenium, and particularly to its inorganic forms, has been hypothesized as a risk factor for amyotrophic lateral sclerosis (ALS), a fast progressing motor neuron disease with poorly understood etiology. However, no information is known about levels of inorganic and some organic selenium species in the central nervous system of ALS patients, and recent observations suggest that peripheral biomarkers of exposure are unable to predict these levels for several Se species including the inorganic forms. Using a hospital-referred case–control series and advanced selenium speciation methods, we compared the chemical species of selenium in cerebrospinal fluid from 38 ALS patients to those of 38 reference neurological patients matched on age and gender. We found that higher concentrations of inorganic selenium in the form of selenite and of human serum albumin-bound selenium were associated with increased ALS risk (relative risks 3.9 (95% confidence interval 1.2–11.0) and 1.7 (1.0–2.9) for 0.1 μg/L increas

KW - Selenium

KW - Selenite

KW - Selenoprotein-P

KW - Amyotrophic lateral sclerosis

KW - Case–control study

KW - Cerebrospinal fluid

KW - Risk

KW - Environment

KW - Speciation analysis

U2 - 10.1016/j.neuro.2013.05.016

DO - 10.1016/j.neuro.2013.05.016

M3 - Article

VL - 38

SP - 25

EP - 32

JO - NeuroToxicology

JF - NeuroToxicology

SN - 0161-813X

ER -