Nine SHRIMP U/Pb ages on zircon and two Pb/Pb single zircon ages have been determined from Late Paleozoic volcanic rocks from Saxony and northern Bohemia. Samples came from the Teplice-Altenberg Volcanic Complex, the Meissen Volcanic Complex, the Chemnitz Basin, the Döhlen Basin, the Brandov-Olbernhau Basin, and the North Saxon Volcanic Complex. The Teplice-Altenberg Volcanic Complex is subdivided into an early Namurian phase (Mikulov Ignimbrite, 326.8 ± 4.3 Ma), thus older than assumed by previous studies, and a late caldera-forming phase (Teplice Ignimbrite, 308.8 ± 4.9 Ma). The age of the latter, however, is not well constrained due to a large population of inherited zircon and possible hydrothermal overprint. The Leutewitz Ignimbrite, product of an early explosive volcanic episode of the Meissen Volcanic Complex yielded an age of 302.9 ± 2.5 Ma (Stephanian A). Volcanic rocks intercalated in the Brandov-Olbernhau Basin (BOB, 302 ± 2.8 Ma), Chemnitz Basin (CB, 296.6 ± 3.0 Ma), Döhlen Basin (DB, 296 ± 3.0 Ma), and the North Saxon Volcanic Complex (NSVC, c. 300-290 Ma) yielded well-constrained Stephanian to Sakmarian ages. The largest Late Paleozoic ignimbrite-forming eruption in Central Europe, the Rochlitz Ignimbrite, has a well-defined middle Asselian age of 294.4 ± 1.8 Ma. Ages of palingenic zircon revealed that the Namurian-Westphalian magmatism assimilated larger amounts of crystalline basement that formed during previous Paleozoic geodynamic phases. The Precambrian inherited ages support the chronostratigraphic structure assumed for the Saxo-Thuringian Zone of the Variscan Orogen. The present results help to improve the chronostratigraphic allocation of the Late Paleozoic volcanic zones in Central Europe. At the same time, the radiometric ages have implications for the interbasinal correlation and for the geodynamic evolution of the Variscan Orogeny.