Abstract The comprehensive literature data and our findings about calcium-regulating hormones participant in the glucose metabolism is analyzed. It is showed calcitonin hyperglycemic effect and its mechanisms, established contra-insulin effect of calcitonin to insulin under the pre-receptor, cell level and liver. It is ascertained the impairment of glucose metabolism under calcitonin - hyperglycemia, insulin resistance and glucose intolerance. It is showed the data of combinative effect of calcitonin and calcium antagonists on glucose metabolism. It is discussed calcitonin diabetogenic effect and the role of calcium antagonists in the correction of hyperglycemia and tissue's insulin resistance. It was revealed the effect of parathyrin on glucose, occurring in decreasing the glucose level and increases glucose tolerance. It is concluded about participant of calcium-regulating hormones in the regulation of glucose metabolism.