BRAF V600E expression in papillary thyroid carcinoma in North-Western Russia, its relationship with the morphological features of the tumor

Standard

BRAF V600E expression in papillary thyroid carcinoma in North-Western Russia, its relationship with the morphological features of the tumor. / Semenov, Arseny ; Chernikov, Roman; Bubnov, Alexander; Vorobev, Sergey; Kulyash, Alexey; Pavlova, Irina; Sleptsov, Ilya; Makarin, Viktor; Timofeeva, Nataly; Uspenskaya, Anna; Karelina, Julia; Chinchuk, Igor; Novokshonov, Konstantin; Fedorov, Elisey; Fedotov, Yriy.

в: Langenbeck's Archives of Surgery, Том 398, 2013.

Результаты исследований: Научные публикации в периодических изданиях › тезисы › Рецензирование

Author

Semenov, Arseny ; Chernikov, Roman ; Bubnov, Alexander ; Vorobev, Sergey ; Kulyash, Alexey ; Pavlova, Irina ; Sleptsov, Ilya ; Makarin, Viktor ; Timofeeva, Nataly ; Uspenskaya, Anna ; Karelina, Julia ; Chinchuk, Igor ; Novokshonov, Konstantin ; Fedorov, Elisey ; Fedotov, Yriy. / BRAF V600E expression in papillary thyroid carcinoma in North-Western Russia, its relationship with the morphological features of the tumor. в: Langenbeck's Archives of Surgery. 2013 ; Том 398.

BibTeX

@article{f7d6a77eb1354adc927232fd605464b8,

title = "BRAF V600E expression in papillary thyroid carcinoma in North-Western Russia, its relationship with the morphological features of the tumor",

abstract = "Background: BRAF V600E mutation is one of the most common findings in papillary thyroid carcinoma. Reported prevalence of the mutation in different populations differs much, and its tactical importance may also vary. Methods: We investigated the expression of the BRAF V600E gene in frozen tumor tissue dissected from operating material in a series of 100 consecutive patients with papillary thyroid carcinoma operated in the Department of Endocrine Surgery using a kit of KRAS-BRAF StripAssay (Viennalab). Then, tumor was examined in the Department of Pathology, and diagnosis of papillary thyroid cancer was verified in all cases. Results: In 90 (90 %) cases was determined expression of BRAF. We evaluated the specificity and sensitivity of detection of the mutation on a number of morphological features of the tumor affecting the prognosis, such as follicular type (specificity was 79.2 % and sensitivity was 7.6 %), Warthin-like type of papillary carcinoma (100.0 %/11.4 %), B-cell form (89.5 %/11.3 % resp.), Tall-c",

author = "Arseny Semenov and Roman Chernikov and Alexander Bubnov and Sergey Vorobev and Alexey Kulyash and Irina Pavlova and Ilya Sleptsov and Viktor Makarin and Nataly Timofeeva and Anna Uspenskaya and Julia Karelina and Igor Chinchuk and Konstantin Novokshonov and Elisey Fedorov and Yriy Fedotov",

year = "2013",

doi = "10.1007/s00423-013-1078-1",

language = "English",

volume = "398",

journal = "Langenbeck's Archives of Surgery",

issn = "1435-2443",

publisher = "Springer Nature",

note = "5th ESES WORKSHOP—Surgery of Thyroid Cancer ; Conference date: 23-05-2013 Through 25-05-2013",

}

RIS

TY - JOUR

T1 - BRAF V600E expression in papillary thyroid carcinoma in North-Western Russia, its relationship with the morphological features of the tumor

AU - Semenov, Arseny

AU - Chernikov, Roman

AU - Bubnov, Alexander

AU - Vorobev, Sergey

AU - Kulyash, Alexey

AU - Pavlova, Irina

AU - Sleptsov, Ilya

AU - Makarin, Viktor

AU - Timofeeva, Nataly

AU - Uspenskaya, Anna

AU - Karelina, Julia

AU - Chinchuk, Igor

AU - Novokshonov, Konstantin

AU - Fedorov, Elisey

AU - Fedotov, Yriy

PY - 2013

Y1 - 2013

N2 - Background: BRAF V600E mutation is one of the most common findings in papillary thyroid carcinoma. Reported prevalence of the mutation in different populations differs much, and its tactical importance may also vary. Methods: We investigated the expression of the BRAF V600E gene in frozen tumor tissue dissected from operating material in a series of 100 consecutive patients with papillary thyroid carcinoma operated in the Department of Endocrine Surgery using a kit of KRAS-BRAF StripAssay (Viennalab). Then, tumor was examined in the Department of Pathology, and diagnosis of papillary thyroid cancer was verified in all cases. Results: In 90 (90 %) cases was determined expression of BRAF. We evaluated the specificity and sensitivity of detection of the mutation on a number of morphological features of the tumor affecting the prognosis, such as follicular type (specificity was 79.2 % and sensitivity was 7.6 %), Warthin-like type of papillary carcinoma (100.0 %/11.4 %), B-cell form (89.5 %/11.3 % resp.), Tall-c

AB - Background: BRAF V600E mutation is one of the most common findings in papillary thyroid carcinoma. Reported prevalence of the mutation in different populations differs much, and its tactical importance may also vary. Methods: We investigated the expression of the BRAF V600E gene in frozen tumor tissue dissected from operating material in a series of 100 consecutive patients with papillary thyroid carcinoma operated in the Department of Endocrine Surgery using a kit of KRAS-BRAF StripAssay (Viennalab). Then, tumor was examined in the Department of Pathology, and diagnosis of papillary thyroid cancer was verified in all cases. Results: In 90 (90 %) cases was determined expression of BRAF. We evaluated the specificity and sensitivity of detection of the mutation on a number of morphological features of the tumor affecting the prognosis, such as follicular type (specificity was 79.2 % and sensitivity was 7.6 %), Warthin-like type of papillary carcinoma (100.0 %/11.4 %), B-cell form (89.5 %/11.3 % resp.), Tall-c

U2 - 10.1007/s00423-013-1078-1

DO - 10.1007/s00423-013-1078-1

M3 - Meeting Abstract

VL - 398

JO - Langenbeck's Archives of Surgery

JF - Langenbeck's Archives of Surgery

SN - 1435-2443

T2 - 5th ESES WORKSHOP—Surgery of Thyroid Cancer

Y2 - 23 May 2013 through 25 May 2013

ER -

ID: 128107644