The article covers epidemiologic analysis of medical staff health state, epidemiologic evaluation of biologic factor's influence (degree and character of) on clinical staff, detection of principal risk factors for being infected. The aim is to create a supervision system and to elaborate effective measures for occupational risk prevention in medical personnel. Organizing a goal-seeking and effective system for occupational risk prevention and health care in medical staff, one should consider specificity in each medical establishment and in each occupational task.