The urgent task of modern care of public health is developing completely brand-new, "smart" drug formulations that can provide a superior therapeutic efficacy with a minimum of side effects. Moreover, the research in this direction might able to achieve the unexpected decisions when choosing therapy for various, including widespread and extremely dangerous, diseases. In particular, biodegradable nanocontainers with stipulated physical and chemical (particle size, size distribution, degradation rate of chemical bonds defined by a structure of polymer) characteristics of nanoparticles, as well as biological (biomimetic) properties of their surface, which smoothly invaded in the natural processes of human body, enable to provide such results. The aim of presented research is design and synthesis of special biologically functionalized nanoconstructs based on nanoparticles of various chemical nature, including those modified with biofunctional gold nanoclusters, which have been recently developed in our team. The