Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Biocompatibility, antioxidant activity and collagen photoprotection properties of C60 fullerene adduct with L-methionine. / Sharoyko, Vladimir V. ; Shemchuk, Olga S. ; Meshcheriakov, Anatolii A. ; Vasina, Lubov V. ; Iamalova, Nailia R. ; Luttsev, Michail D. ; Ivanova, Daria A. ; Petrov, Andrey V. ; Maystrenko, Dmitriy N. ; Molchanov, Oleg E. ; Semenov, Konstantin N. .
в: Nanomedicine: Nanotechnology, Biology, and Medicine, Том 40, 102500, 02.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Biocompatibility, antioxidant activity and collagen photoprotection properties of C60 fullerene adduct with L-methionine
AU - Sharoyko, Vladimir V.
AU - Shemchuk, Olga S.
AU - Meshcheriakov, Anatolii A.
AU - Vasina, Lubov V.
AU - Iamalova, Nailia R.
AU - Luttsev, Michail D.
AU - Ivanova, Daria A.
AU - Petrov, Andrey V.
AU - Maystrenko, Dmitriy N.
AU - Molchanov, Oleg E.
AU - Semenov, Konstantin N.
N1 - Publisher Copyright: © 2021 Elsevier Inc.
PY - 2022/2
Y1 - 2022/2
N2 - Functionalization of the fullerene core with amino acids has become a new and promising direction in the field of nanochemistry. The biologic activity of water-soluble fullerene derivatives is based on such properties as lipophilicity, electron deficiency and photosensitivity. The complex of above-mentioned properties can be used to develop protection of biomolecules (in particular, proteins) from external physical and chemical influences. Thus, development and up-scaling of synthesis procedures, as well as investigation of the biological properties of these derivatives, are extremely important. This paper presents new data on the biocompatibility studies of C60 fullerene adduct with L-methionine (C60[C5H11NO2S]3; C60-Met). Antiradical activity, binding to human serum albumin (HSA), collagen and deoxyribonucleic acid (DNA), hemocompatibility, photodynamic properties, genotoxicity and cytotoxicity were studied. In addition, it was found that C60-Met increases the photostability of the collagen molecule, and this effect is dose-dependent.
AB - Functionalization of the fullerene core with amino acids has become a new and promising direction in the field of nanochemistry. The biologic activity of water-soluble fullerene derivatives is based on such properties as lipophilicity, electron deficiency and photosensitivity. The complex of above-mentioned properties can be used to develop protection of biomolecules (in particular, proteins) from external physical and chemical influences. Thus, development and up-scaling of synthesis procedures, as well as investigation of the biological properties of these derivatives, are extremely important. This paper presents new data on the biocompatibility studies of C60 fullerene adduct with L-methionine (C60[C5H11NO2S]3; C60-Met). Antiradical activity, binding to human serum albumin (HSA), collagen and deoxyribonucleic acid (DNA), hemocompatibility, photodynamic properties, genotoxicity and cytotoxicity were studied. In addition, it was found that C60-Met increases the photostability of the collagen molecule, and this effect is dose-dependent.
KW - Biological activity
KW - Collagen
KW - Fullerenes
KW - L-Methionine
KW - Ultra-violet light
UR - https://www.mendeley.com/catalogue/7598c055-c12a-3399-8c84-7336bf3a94bd/
UR - http://www.scopus.com/inward/record.url?scp=85121909913&partnerID=8YFLogxK
U2 - 10.1016/j.nano.2021.102500
DO - 10.1016/j.nano.2021.102500
M3 - Article
VL - 40
JO - Nanomedicine: Nanotechnology, Biology, and Medicine
JF - Nanomedicine: Nanotechnology, Biology, and Medicine
SN - 1549-9634
M1 - 102500
ER -
ID: 89393165