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Beta-adrenergicheskaia reguliatsiia aktivnosti Na, K-ATFazy sarkolemmy serdechnoǐ myshtsy. / Osadchaia, L. M.; Mugula, Z.; Stefanov, V. E.

в: Nauchnye doklady vysshei shkoly. Biologicheskie nauki, № 6, 1990, стр. 138-147.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Osadchaia, LM, Mugula, Z & Stefanov, VE 1990, 'Beta-adrenergicheskaia reguliatsiia aktivnosti Na, K-ATFazy sarkolemmy serdechnoǐ myshtsy.', Nauchnye doklady vysshei shkoly. Biologicheskie nauki, № 6, стр. 138-147.

APA

Osadchaia, L. M., Mugula, Z., & Stefanov, V. E. (1990). Beta-adrenergicheskaia reguliatsiia aktivnosti Na, K-ATFazy sarkolemmy serdechnoǐ myshtsy. Nauchnye doklady vysshei shkoly. Biologicheskie nauki, (6), 138-147.

Vancouver

Osadchaia LM, Mugula Z, Stefanov VE. Beta-adrenergicheskaia reguliatsiia aktivnosti Na, K-ATFazy sarkolemmy serdechnoǐ myshtsy. Nauchnye doklady vysshei shkoly. Biologicheskie nauki. 1990;(6):138-147.

Author

Osadchaia, L. M. ; Mugula, Z. ; Stefanov, V. E. / Beta-adrenergicheskaia reguliatsiia aktivnosti Na, K-ATFazy sarkolemmy serdechnoǐ myshtsy. в: Nauchnye doklady vysshei shkoly. Biologicheskie nauki. 1990 ; № 6. стр. 138-147.

BibTeX

@article{1031e434669943178bbf5c733f8aa927,
title = "Beta-adrenergicheskaia reguliatsiia aktivnosti Na, K-ATFazy sarkolemmy serdechnoǐ myshtsy.",
abstract = "Using a sensitive potentiometric method the effect of isoproterenol upon the activity of Na, K-ATPase in cardiomyocytes has been studied. The activity of the enzyme in rat sarcolemma at isoproterenol-induced myocarditis decreases by 42%. A direct action of isoproterenol on the Na, K-ATPase activity in sarcolemma in vitro has been investigated. In the concentration range 10(-9)-10(-3) M (from receptor-binding up to cardiotoxic) a gradual decrease of the activity reaching the complete inhibition at 10(-3) M is revealed. Antagonist of beta-adrenoreceptors propranolol in concentrations required for displacing the agonist (10(-9) M) provides for the recovery of the Na, K-ATPase activity up to 76% of its normal activity. This action transforms into nonspecific inhibition at rising concentration of the antagonist. Possible mechanisms of the beta-adrenergic regulation effect in cardiomyocytes on Na, K-ATPase of the sarcolemma are discussed.",
author = "Osadchaia, {L. M.} and Z. Mugula and Stefanov, {V. E.}",
year = "1990",
language = "русский",
pages = "138--147",
journal = "Биологические науки",
issn = "1028-0057",
publisher = "Высшая школа",
number = "6",

}

RIS

TY - JOUR

T1 - Beta-adrenergicheskaia reguliatsiia aktivnosti Na, K-ATFazy sarkolemmy serdechnoǐ myshtsy.

AU - Osadchaia, L. M.

AU - Mugula, Z.

AU - Stefanov, V. E.

PY - 1990

Y1 - 1990

N2 - Using a sensitive potentiometric method the effect of isoproterenol upon the activity of Na, K-ATPase in cardiomyocytes has been studied. The activity of the enzyme in rat sarcolemma at isoproterenol-induced myocarditis decreases by 42%. A direct action of isoproterenol on the Na, K-ATPase activity in sarcolemma in vitro has been investigated. In the concentration range 10(-9)-10(-3) M (from receptor-binding up to cardiotoxic) a gradual decrease of the activity reaching the complete inhibition at 10(-3) M is revealed. Antagonist of beta-adrenoreceptors propranolol in concentrations required for displacing the agonist (10(-9) M) provides for the recovery of the Na, K-ATPase activity up to 76% of its normal activity. This action transforms into nonspecific inhibition at rising concentration of the antagonist. Possible mechanisms of the beta-adrenergic regulation effect in cardiomyocytes on Na, K-ATPase of the sarcolemma are discussed.

AB - Using a sensitive potentiometric method the effect of isoproterenol upon the activity of Na, K-ATPase in cardiomyocytes has been studied. The activity of the enzyme in rat sarcolemma at isoproterenol-induced myocarditis decreases by 42%. A direct action of isoproterenol on the Na, K-ATPase activity in sarcolemma in vitro has been investigated. In the concentration range 10(-9)-10(-3) M (from receptor-binding up to cardiotoxic) a gradual decrease of the activity reaching the complete inhibition at 10(-3) M is revealed. Antagonist of beta-adrenoreceptors propranolol in concentrations required for displacing the agonist (10(-9) M) provides for the recovery of the Na, K-ATPase activity up to 76% of its normal activity. This action transforms into nonspecific inhibition at rising concentration of the antagonist. Possible mechanisms of the beta-adrenergic regulation effect in cardiomyocytes on Na, K-ATPase of the sarcolemma are discussed.

UR - http://www.scopus.com/inward/record.url?scp=0025070423&partnerID=8YFLogxK

M3 - статья

C2 - 2169911

AN - SCOPUS:0025070423

SP - 138

EP - 147

JO - Биологические науки

JF - Биологические науки

SN - 1028-0057

IS - 6

ER -

ID: 89843829