BAR Domain Proteins as Putative Regulators of the Protein Liquid Phase in Nerve Terminals in the Central Nervous System

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BAR Domain Proteins as Putative Regulators of the Protein Liquid Phase in Nerve Terminals in the Central Nervous System. / Shishkov, A. G. ; Nifantova, N. V. ; Korenkovaa, O. M. ; Sopova, E. S. ; Brodin, Lennart; Shupliakov, O. .

в: Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology, Том 17, № 2, 18.06.2023, стр. 69-82.

Результаты исследований: Научные публикации в периодических изданиях › Обзорная статья › Рецензирование

BibTeX

@article{5b5b67f3e6b644a5a68cb211e06c3fa5,

title = "BAR Domain Proteins as Putative Regulators of the Protein Liquid Phase in Nerve Terminals in the Central Nervous System",

abstract = "BAR proteins are key components of the synaptic vesicle cycle in nerve terminals. They participatein the regulation of neurotransmitter release during the fusion of synaptic vesicles with the presynaptic membrane and synaptic vesicle recycling. Localization of these proteins at the sites of liquid–liquid phase separation in nerve terminals suggests additional functions of these molecules. In the current review, we discuss thetasks of BAR proteins at different stages of the secretory cycle, including their putative role in liquid–liquidphase transitions in nerve terminals during synaptic activity. We suggest that BAR proteins, along with theirestablished functions in exo- and endocytosis, play crucial roles in the organization of the reserve pool of synaptic vesicles and at intermediate stages of the vesicle cycle.",

keywords = "synapse, synaptic vesicle cycle, exocytosis, endocytosis, BAR proteins, liquid–liquid phase transition, synapse, synaptic vesicle cycle, exocytosis, endocytosis, BAR proteins, liquid–liquid phase transition",

author = "Shishkov, {A. G.} and Nifantova, {N. V.} and Korenkovaa, {O. M.} and Sopova, {E. S.} and Lennart Brodin and O. Shupliakov",

note = "ISSN 1990-7478, Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2023, Vol. 17, No. 2, pp. 69–82. {\textcopyright} Pleiades Publishing, Ltd., 2023. Russian Text {\textcopyright} The Author(s), 2023, published in Biologicheskie Membrany, 2023, Vol. 40, No. 3, pp. 155–171.",

year = "2023",

month = jun,

day = "18",

doi = "10.1134/s199074782303008x",

language = "English",

volume = "17",

pages = "69--82",

journal = "Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology",

issn = "1990-7478",

publisher = "МАИК {"}Наука/Интерпериодика{"}",

number = "2",

}

RIS

TY - JOUR

T1 - BAR Domain Proteins as Putative Regulators of the Protein Liquid Phase in Nerve Terminals in the Central Nervous System

AU - Shishkov, A. G.

AU - Nifantova, N. V.

AU - Korenkovaa, O. M.

AU - Sopova, E. S.

AU - Brodin, Lennart

AU - Shupliakov, O.

N1 - ISSN 1990-7478, Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2023, Vol. 17, No. 2, pp. 69–82. © Pleiades Publishing, Ltd., 2023. Russian Text © The Author(s), 2023, published in Biologicheskie Membrany, 2023, Vol. 40, No. 3, pp. 155–171.

PY - 2023/6/18

Y1 - 2023/6/18

N2 - BAR proteins are key components of the synaptic vesicle cycle in nerve terminals. They participatein the regulation of neurotransmitter release during the fusion of synaptic vesicles with the presynaptic membrane and synaptic vesicle recycling. Localization of these proteins at the sites of liquid–liquid phase separation in nerve terminals suggests additional functions of these molecules. In the current review, we discuss thetasks of BAR proteins at different stages of the secretory cycle, including their putative role in liquid–liquidphase transitions in nerve terminals during synaptic activity. We suggest that BAR proteins, along with theirestablished functions in exo- and endocytosis, play crucial roles in the organization of the reserve pool of synaptic vesicles and at intermediate stages of the vesicle cycle.

AB - BAR proteins are key components of the synaptic vesicle cycle in nerve terminals. They participatein the regulation of neurotransmitter release during the fusion of synaptic vesicles with the presynaptic membrane and synaptic vesicle recycling. Localization of these proteins at the sites of liquid–liquid phase separation in nerve terminals suggests additional functions of these molecules. In the current review, we discuss thetasks of BAR proteins at different stages of the secretory cycle, including their putative role in liquid–liquidphase transitions in nerve terminals during synaptic activity. We suggest that BAR proteins, along with theirestablished functions in exo- and endocytosis, play crucial roles in the organization of the reserve pool of synaptic vesicles and at intermediate stages of the vesicle cycle.

KW - synapse

KW - synaptic vesicle cycle

KW - exocytosis

KW - endocytosis

KW - BAR proteins

KW - liquid–liquid phase transition

KW - synapse

KW - synaptic vesicle cycle

KW - exocytosis

KW - endocytosis

KW - BAR proteins

KW - liquid–liquid phase transition

UR - https://link.springer.com/article/10.1134/s199074782303008x

UR - https://www.mendeley.com/catalogue/143de786-0fc3-30f4-a607-637aa8058113/

U2 - 10.1134/s199074782303008x

DO - 10.1134/s199074782303008x

M3 - Review article

VL - 17

SP - 69

EP - 82

JO - Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

JF - Biochemistry (Moscow) Supplement Series A: Membrane and Cell Biology

SN - 1990-7478

IS - 2

ER -

ID: 104618268