Automated technology for synthesizing [18F]fluoromethylcholine, a radiopharmaceutical for diagnostic positron- emission-tomography tumor imaging, was developed. A TRACERlab FX FN synthesis module (GE Healthcare) used the combined technology of on-line alkylation and solid-phase extraction. The synthesis module was modified to allow operation at various He flow rates in critical process steps. The radiochemical yield of [18F]fluoromethylcholine was >10%, which was sufficient to produce several clinical doses. The quality control parameters of the produced [18F]fluoromethylcholine met the requirements of the RF Pharmacopoeia.