TY - JOUR

T1 - Automated primary amine-based supramolecular solvent microextraction with monoterpenoid as coacervation agent before high-performance liquid chromatography

AU - Жаворонок, Марк Филипп Игоревич

AU - Вах, Кристина Степановна

AU - Булатов, Андрей Васильевич

PY - 2023/3/1

Y1 - 2023/3/1

N2 - The phenomenon of the formation of a supramolecular solvent based on a primary amine during dispersion in the aqueous phase of a homogeneous mixture containing both an amphiphile (primary amine) and a coacervation agent (monoterpenoid) was presented. In this case, the addition of a solid monoterpenoid during microextraction was not required. The established approach has the potential for automation based on a flow system, since only liquid phases are involved in the formation of a supramolecular solvent. An automated primary amine-based supramolecular solvent microextraction technique with monoterpenoid as a coacervation agent was developed. The microextraction procedure was carried out inside a mixing chamber of a flow-batch system. Dispersion of the amphiphile and coacervation agent mixed solution in the phase of the aqueous sample was performed by using air bubbles supplied by a peristaltic pump. The technique was applied to the separation and preconcentration of bisphenol A from beverages for its chromatographic determination as a model analytical method. The supramolecular solvent precursors mixed solution contained both 1-hexylamine and menthol provided extract phase separation without centrifugation, high extraction recovery (90 ± 8 %), and compatibility of the extract phase with a mobile phase used for chromatographic analysis. The linear range was 2–5000 µg L−1 with a determination coefficient of 0.999. The limit of detection calculated from a blank test based on 3σ was 0.7 µg L−1. The limit of quantification calculated from a blank test based on 10 σ was 2 µg L−1. The enrichment factor was found to be 10.4. The intra-day repeatability was less than 8 % while inter-day repeatability was less than 10 %; relative recovery values were in the range of 84–102 %.

AB - The phenomenon of the formation of a supramolecular solvent based on a primary amine during dispersion in the aqueous phase of a homogeneous mixture containing both an amphiphile (primary amine) and a coacervation agent (monoterpenoid) was presented. In this case, the addition of a solid monoterpenoid during microextraction was not required. The established approach has the potential for automation based on a flow system, since only liquid phases are involved in the formation of a supramolecular solvent. An automated primary amine-based supramolecular solvent microextraction technique with monoterpenoid as a coacervation agent was developed. The microextraction procedure was carried out inside a mixing chamber of a flow-batch system. Dispersion of the amphiphile and coacervation agent mixed solution in the phase of the aqueous sample was performed by using air bubbles supplied by a peristaltic pump. The technique was applied to the separation and preconcentration of bisphenol A from beverages for its chromatographic determination as a model analytical method. The supramolecular solvent precursors mixed solution contained both 1-hexylamine and menthol provided extract phase separation without centrifugation, high extraction recovery (90 ± 8 %), and compatibility of the extract phase with a mobile phase used for chromatographic analysis. The linear range was 2–5000 µg L−1 with a determination coefficient of 0.999. The limit of detection calculated from a blank test based on 3σ was 0.7 µg L−1. The limit of quantification calculated from a blank test based on 10 σ was 2 µg L−1. The enrichment factor was found to be 10.4. The intra-day repeatability was less than 8 % while inter-day repeatability was less than 10 %; relative recovery values were in the range of 84–102 %.

KW - Beverages

KW - Bisphenol A

KW - HPLC-FLD

KW - Microextraction

KW - Monoterpenoid

KW - Primary amine

KW - Supramolecular solvent

UR - https://www.mendeley.com/catalogue/e6acc986-2ec7-362b-9d39-84c7298694c0/

U2 - 10.1016/j.jfca.2022.105085

DO - 10.1016/j.jfca.2022.105085

M3 - Article

VL - 116

JO - Journal of Food Composition and Analysis

JF - Journal of Food Composition and Analysis

SN - 0889-1575

M1 - 105085

ER -