TY - JOUR

T1 - Autoimmune diseases of digestive system

AU - Ivashkin, V. T.

AU - Sheptulina, A. F.

AU - Raikhelson, K. L.

AU - Losik, E. A.

AU - Ivashkin, K. V.

AU - Okhlobystin, A. V.

AU - Baranskaya, E. K.

AU - Polouektova, E. A.

AU - Shifrin, O. S.

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Autoimmune diseases of digestive system refer to pathological conditions, caused by autoimmune mechanisms, and their etiology remains unknown. This is a group of relatively rare diseases, however, during the last years a marked tendency towards the raise in incidence and prevalence is observed, which led to an increase in number of clinical investigations on etiology, pathogenesis, and, accordingly, development of new diagnostic methods and therapies. Results of such trials shown, for example, that the pathogenesis of chronic cholestatic liver diseases is associated with nuclear receptors function, while the main etiological and pathogenic factor of inflammatory bowel diseases represents gut microbiota. Despite new achievements in autoimmune diseases of digestive system research, therapies are low effective and are accompanied by a huge number of adverse events. The fact that these diseases may lead to malignant tumors is also worth noting. For example, patients with primary sclerosing cholangitis have a 160 times higher risk of cholangiocellular carcinoma, while 10-14% of patients with celiac disease may develop malignancies of esophagus, small and large intestine. Thus, these diseases require further investigation with a purpose of more accurate diagnostic methods for the detection of disease at early stages and new effective and safe therapies development.

AB - Autoimmune diseases of digestive system refer to pathological conditions, caused by autoimmune mechanisms, and their etiology remains unknown. This is a group of relatively rare diseases, however, during the last years a marked tendency towards the raise in incidence and prevalence is observed, which led to an increase in number of clinical investigations on etiology, pathogenesis, and, accordingly, development of new diagnostic methods and therapies. Results of such trials shown, for example, that the pathogenesis of chronic cholestatic liver diseases is associated with nuclear receptors function, while the main etiological and pathogenic factor of inflammatory bowel diseases represents gut microbiota. Despite new achievements in autoimmune diseases of digestive system research, therapies are low effective and are accompanied by a huge number of adverse events. The fact that these diseases may lead to malignant tumors is also worth noting. For example, patients with primary sclerosing cholangitis have a 160 times higher risk of cholangiocellular carcinoma, while 10-14% of patients with celiac disease may develop malignancies of esophagus, small and large intestine. Thus, these diseases require further investigation with a purpose of more accurate diagnostic methods for the detection of disease at early stages and new effective and safe therapies development.

KW - Autoantibodies

KW - Autoimmune diseases

KW - Digestive system

KW - Nuclear receptors

UR - http://www.scopus.com/inward/record.url?scp=84940979011&partnerID=8YFLogxK

U2 - 10.15690/vramn.v70i2.1306

DO - 10.15690/vramn.v70i2.1306

M3 - статья

C2 - 26234085

AN - SCOPUS:84940979011

VL - 70

SP - 139

EP - 151

JO - ВЕСТНИК РОССИЙСКОЙ АКАДЕМИИ МЕДИЦИНСКИХ НАУК

JF - ВЕСТНИК РОССИЙСКОЙ АКАДЕМИИ МЕДИЦИНСКИХ НАУК

SN - 0869-6047

IS - 2

ER -