Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Audiogenic epilepsy : Morphofunctional analysis. / Batuev, A. S.; Bragina, T. A.; Alexandrov, A. S.; Riabinskaja, E. A.
в: Zhurnal Vysshei Nervnoi Deyatelnosti Imeni I.P. Pavlova, Том 47, № 2, 1997, стр. 437-438.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Audiogenic epilepsy
T2 - Morphofunctional analysis
AU - Batuev, A. S.
AU - Bragina, T. A.
AU - Alexandrov, A. S.
AU - Riabinskaja, E. A.
PY - 1997
Y1 - 1997
N2 - The rats of K-M line with high level of convulsive readiness to sound stimuli were tested. It was established that systemic application of epileptogenic stimulus evoked the decrease of level of convulsive readiness. The phenomena of habituation and normalization of animal behavior were revealed. The intraperitoneal injection of inhibitory transmitter - GABA and taurine (separately or in mixture) blocked the convulsive seizures. The functional influence by KCl-induced spreading depression in the cerebral cortex bilaterally impairs the inhibitory processes, but not the changes the form of epileptiform seizure. In neurophysiological experiments using microelectrophoresis technique it was shown that taurine as inhibitory agent is more effective when applied to dendritic layers II-III; GABA is more effective if it is applied on soma of cortical pyramidal cells. Using the electron microscopic methods, the following changes were observed during the clonic seizure: axo-dendritic and axo-spine synapses in rat auditory cortex were activated. After the habituation to the epileptogenous stimulus, some features evidencing the decrease of activity were observed in ultrastructure of synapses in layers II-III. In 2 days after that the majority of ultrastructural shifts were normalized. Role of calcium ions in generation of epileptic seizures and their depression as main factor of antiepileptic mechanisms is discussed.
AB - The rats of K-M line with high level of convulsive readiness to sound stimuli were tested. It was established that systemic application of epileptogenic stimulus evoked the decrease of level of convulsive readiness. The phenomena of habituation and normalization of animal behavior were revealed. The intraperitoneal injection of inhibitory transmitter - GABA and taurine (separately or in mixture) blocked the convulsive seizures. The functional influence by KCl-induced spreading depression in the cerebral cortex bilaterally impairs the inhibitory processes, but not the changes the form of epileptiform seizure. In neurophysiological experiments using microelectrophoresis technique it was shown that taurine as inhibitory agent is more effective when applied to dendritic layers II-III; GABA is more effective if it is applied on soma of cortical pyramidal cells. Using the electron microscopic methods, the following changes were observed during the clonic seizure: axo-dendritic and axo-spine synapses in rat auditory cortex were activated. After the habituation to the epileptogenous stimulus, some features evidencing the decrease of activity were observed in ultrastructure of synapses in layers II-III. In 2 days after that the majority of ultrastructural shifts were normalized. Role of calcium ions in generation of epileptic seizures and their depression as main factor of antiepileptic mechanisms is discussed.
UR - http://www.scopus.com/inward/record.url?scp=0345908496&partnerID=8YFLogxK
M3 - статья
AN - SCOPUS:0345908496
VL - 47
SP - 437
EP - 438
JO - ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА
JF - ЖУРНАЛ ВЫСШЕЙ НЕРВНОЙ ДЕЯТЕЛЬНОСТИ ИМ. И.П. ПАВЛОВА
SN - 0044-4677
IS - 2
ER -
ID: 18469253