Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
A selectively antimycobacterial compound belonging to the nitrofuran class of antimicrobials has been developed via conjugation of the nitrofuran moiety to a series of spirocyclic piperidines through an amide linkage. It proved to have comparable activity against drug-sensitive (H37Rv) strain as well as multidrug-resistant, patient-derived strains of Mycobacterium tuberculosis. The compound is druglike, showed no appreciable cytotoxicity toward human retinal pigment epithelial cell line ARPE-19 in concentrations up to 100 μM and displayed low toxicity when evaluated in mice.
Язык оригинала | английский |
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Страницы (с-по) | 125-135 |
Число страниц | 11 |
Журнал | European Journal of Medicinal Chemistry |
Том | 166 |
DOI | |
Состояние | Опубликовано - 15 мар 2019 |
ID: 39059313