Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
ATP concentration as possible marker of liver damage at leukaemia treatment : Confocal microscopy-based experimental study and numerical simulations. / Malashchenko, V.; Zyubin, A.; Babak, S.; Lavrova, A.
Saratov Fall Meeting 2016: Laser Physics and Photonics XVII; and Computational Biophysics and Analysis of Biomedical Data III. Том 10337 SPIE, 2017. 103371B.Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
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TY - GEN
T1 - ATP concentration as possible marker of liver damage at leukaemia treatment
T2 - 4th International Symposium on Optics and Biophotonics, SFM 2016
AU - Malashchenko, V.
AU - Zyubin, A.
AU - Babak, S.
AU - Lavrova, A.
PY - 2017/1/1
Y1 - 2017/1/1
N2 - We consider the method of confocal microscopy as a convenient instrument for determination of chemical compounds in biological tissues and cells. In particular, we study the dynamics of adenosine triphosphate (ATP) concentration that could be used as a bio-marker of energy metabolism pathologies at the treatment of acute lymphoblastic leukaemia (ALL). On the basis of data obtained by the confocal microscopy, the values of ATP concentration have been calculated for each case. Possible correlations with other characteristics of pathology processes obtained from plasma of leukemia patients show that ATP value could be a prognostic factor of the treatment success. The role of ATP in the drug metabolism switching is also discussed within the context of kinetic modelling of metabolism processes leading to the production of 6-Thioguanosine monophosphate, which is a principal acting agent in chemotherapy.
AB - We consider the method of confocal microscopy as a convenient instrument for determination of chemical compounds in biological tissues and cells. In particular, we study the dynamics of adenosine triphosphate (ATP) concentration that could be used as a bio-marker of energy metabolism pathologies at the treatment of acute lymphoblastic leukaemia (ALL). On the basis of data obtained by the confocal microscopy, the values of ATP concentration have been calculated for each case. Possible correlations with other characteristics of pathology processes obtained from plasma of leukemia patients show that ATP value could be a prognostic factor of the treatment success. The role of ATP in the drug metabolism switching is also discussed within the context of kinetic modelling of metabolism processes leading to the production of 6-Thioguanosine monophosphate, which is a principal acting agent in chemotherapy.
KW - acute lymphoblastic leukemia
KW - adenosine triphosphate concentration
KW - confocal microscopy
KW - numeri-cal simulations
UR - http://www.scopus.com/inward/record.url?scp=85018871475&partnerID=8YFLogxK
U2 - 10.1117/12.2267951
DO - 10.1117/12.2267951
M3 - Conference contribution
AN - SCOPUS:85018871475
VL - 10337
BT - Saratov Fall Meeting 2016
PB - SPIE
Y2 - 26 September 2016 through 29 September 2016
ER -
ID: 27612063